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Yin‐zhi‐huang (YZH) injection is an injectable multiherbal prescription derived from the ancient Chinese medicine formula of Yin‐chen‐hao‐tang, which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, the systematic study of the components in this multiherbal prescription still lacks suitable analytical methods that are able to simultaneously detect a broad...
A simple, specific and sensitive LC‐MS/MS method was developed and validated for the simultaneous determination of metoprolol (MET), α‐hydroxymetoprolol (HMT) and O‐desmethylmetoprolol (DMT) in rat plasma. The plasma samples were prepared by protein precipitation, then the separation of the analytes was performed on an Agilent HC‐C18 column (4.6 × 250 mm, 5 µm) at a flow rate of 1.0 mL/min, and post‐column...
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