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Objective
To confirm and investigate why pathological high‐frequency oscillations (pHFOs), including ripples (80–200 Hz) and fast ripples (200–600 Hz), are generated during the UP‐DOWN transition of the slow wave and if information transmission mediated by ripple temporal coupling is disrupted in the seizure‐onset zone (SOZ).
Methods
We isolated 217 total units from 175.95 intracranial electroencephalography...
Objective
Sleep strongly activates interictal epileptic activity through an unclear mechanism. We investigated how scalp sleep slow waves (SSWs), whose positive and negative half‐waves reflect the fluctuation of neuronal excitability between the up and down states, respectively, modulate interictal epileptic events in focal epilepsy.
Methods
Simultaneous polysomnography was performed in 45 patients...
Objective
Focal cortical dysplasia type II (FCDII) is a malformation of cortex development commonly found in children with drug‐resistant epilepsy. FCDII has been associated with somatic mutations in mammalian target of rapamycin (mTOR)‐related pathway genes and an upregulation of mTOR. Somatic mutations were found in 10%‐63% of FCDII samples; the frequency of the mutant allele was 0.93%‐33.5%. This...
Objective
To evaluate the localization value and prognostic significance of subclinical seizures (SCSs) on scalp video‐electroencephalography monitoring (VEEG) in comparison to clinical seizures (CSs) in patients who had epilepsy surgery.
Methods
We included 123 consecutive patients who had SCSs and CSs during scalp‐VEEG evaluation. All patients had subsequent epilepsy surgery and at least 1‐year...
Objective
The epileptogenic network underlying secondarily generalized tonic–clonic seizures (sGTCS) in mesial temporal lobe epilepsy (mTLE) is not well understood. Here, we investigated alterations in the probabilistic hippocampal‐thalamic pathway (pHTP) underlying sGTCS using diffusion tensor imaging and resting‐state functional magnetic resonance imaging in a cohort of TLE patients with hippocampal...
Objective
Focal cortical dysplasia (FCD) is a major pathology in patients undergoing surgical resection to treat pharmacoresistant epilepsy. Magnetic resonance imaging (MRI) postprocessing methods may provide essential help for detection of FCD. In this study, we utilized surface‐based MRI morphometry and machine learning for automated lesion detection in a mixed cohort of patients with FCD type...
PurposeThe orbitofrontal (OF) region is one of the least explored regions of the cerebral cortex. There are few studies on patients with electrophysiologically and surgically confirmed OF epilepsy and a negative magnetic resonance imaging (MRI) study. We aimed to examine the neuroimaging characteristics of MRI‐negative OF epilepsy with the focus on a voxel‐based morphometric MRI postprocessing technique...
Purpose: Fast ripples are reported to be highly localizing to the epileptogenic or seizure‐onset zone (SOZ) but may not be readily found in neocortical epilepsy, whereas ripples are insufficiently localizing. Herein we classified interictal neocortical ripples by associated characteristics to identify a subtype that may help to localize the SOZ in neocortical epilepsy. We hypothesize that ripples...
The present study was designed to determine whether low‐frequency stimulation (LFS) of the entorhinal cortex (EC) has an anticonvulsive effect, and whether LFS delivered at different times plays different roles. We found that LFS of the EC immediately or 4 s after kindling stimulation had an anticonvulsive effect, and that the latter had a better effect on both kindling and kindled seizures. However,...
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