Sulphonylurea receptors (SURs) serve as regulatory subunits of ATP-sensitive K+ channels. SURs are members of the ATP-binding cassette (ABC) protein superfamily and contain two conserved nucleotide-binding domains (NBDs) which bind and hydrolyse MgATP; in addition, they carry the binding sites for the sulphonylureas like glibenclamide (GBC) which close the channel and for the KATP channel openers...
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