Search results for: Roza Pawlowska

Items from 1 to 5 out of 5 results

article

A way to understand idiopathic senescence and apoptosis in primary glioblastoma cells – possible approaches to circumvent these phenomena

Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, more

BMC Cancer > 2019 > 19 > 1 > 1-16

Background Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound insight into its biology and thus, facilitate development and testing of new therapeutic approaches. Unfortunately, stable glioblastoma cell lines do not reflect highly heterogeneous nature of this tumor, while its primary cultures are difficult to maintain...

article

Fluorescence and confocal imaging of mammalian cells using conjugated oligoelectrolytes with phenylenevinylene core

Justyna Milczarek, Roza Pawlowska, Remigiusz Zurawinski, Beata Lukasik, more

Journal of Photochemistry and Photobiology B: Biology > 2017 > 170 > C > 40-48

Over the last few years, considerable efforts are taken, in order to find a molecular fluorescent probe fulfilling their applicability requirements. Due to a good optical properties and affinity to biological structures conjugated oligoelectrolytes (COEs) can be considered as a promising dyes for application in fluorescence-based bioimaging. In this work, we synthetized COEs with phenylenevinylene...

article

The α-thio and/or β-γ-hypophosphate analogs of ATP as cofactors of T4 DNA ligase

Roza Pawlowska, Dariusz Korczynski, Barbara Nawrot, Wojciech J. Stec, more

Bioorganic Chemistry > 2016 > 67 > C > 110-115

T4 DNA ligase is one of the most commonly used enzymes for in vitro molecular research and a useful model for testing the ligation mechanism of ATP-dependent DNA ligation. To better understand the influence of phosphate group modifications in the ligation process, a series of ATP analogs were tested as cofactors. P-diastereomers of newly developed β,γ-hypo-ATPαS (thio) and β,γ-hypo-ATP (oxo) were...

article

RNA fragments mimicking tRNA analogs interact with cytochrome c

Roza Pawlowska, Magdalena Janicka, Dominika Jedrzejczyk, Arkadiusz Chworos

Molecular Biology Reports > 2016 > 43 > 4 > 295-304

In times, when drug seeking assays focus on the natural molecular triggers and their analogs, a deeper insight into molecular mechanisms governing the initial step of intrinsic apoptosis (cytochrome c release) is essential to suppress the immortality of pathologically changed cells. In this study, we examined RNA molecules mimicking mitochondrial tRNAs interacting with cytochrome c and possibly affecting...

article

Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5′-O-monophosphorothioate and their derivatives — Implication for desulfuration process in the cell

Agnieszka Krakowiak, Róża Pawłowska, Beata Kocoń-Rębowska, Rafał Dolot, more

BBA - General Subjects > 2014 > 1840 > 12 > 3357-3366

One of the activities of histidine triad nucleotide-binding protein 1 (Hint1) under in vitro conditions is the conversion of nucleoside 5′-O-phosphorothioate (NMPS) to its 5′-O-phosphate (NMP), which is accompanied by the release of hydrogen sulfide.Non-hydrolyzable derivatives of AMPS and dCMPS, each containing the residue able to form a covalent bond in nucleic acid–protein complexes via photocrosslinking...

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Search results for: Roza Pawlowska

A way to understand idiopathic senescence and apoptosis in primary glioblastoma cells – possible approaches to circumvent these phenomena

Fluorescence and confocal imaging of mammalian cells using conjugated oligoelectrolytes with phenylenevinylene core

The α-thio and/or β-γ-hypophosphate analogs of ATP as cofactors of T4 DNA ligase

RNA fragments mimicking tRNA analogs interact with cytochrome c

Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5′-O-monophosphorothioate and their derivatives — Implication for desulfuration process in the cell

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