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The detrusor, a key component of the urinary bladder wall, is a densely innervated syncytial smooth muscle tissue. Random spontaneous release of neurotransmitter at neuromuscular junctions (NMJs) in the detrusor gives rise to spontaneous excitatory junction potentials (SEJPs). These sub-threshold passive signals not only offer insights into the syncytial nature of the tissue, their spatio-temporal...
The urinary bladder wall is composed of the detrusor smooth muscle (DSM) in which adjacent cells are electrically coupled to form a three dimensional syncytium. The structural complexity of the tissue is further enhanced by a distributed innervation pattern. Experimental techniques employed in order to analyze detrusor excitability have been unable as yet to provide a satisfactory understanding of...
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