Search results for: Lei Zhang

Items from 1 to 20 out of 7,936 results

article

Versatile and Highly Efficient Controls of Reversible Topotactic Metal–Insulator Transitions through Proton Intercalation

Shanquan Chen, Haiping Zhou, Xing Ye, Zuhuang Chen, more

Advanced Functional Materials > 29 > 50 > n/a - n/a

The ability to tailor a new crystalline structure and associated functionalities with a variety of stimuli is one of the key issues in material design. Developing synthetic routes to functional materials with partially absorbed nonmetallic elements (i.e., hydrogen and nitrogen) can open up more possibilities for preparing novel families of electronically active oxide compounds. Fast and reversible...

article

ZnO‐Based Ultraviolet Photodetectors with Tunable Spectral Responses

Meijuan Zheng, Yalun Xu, Xiao Wang, Guozhen Zhang, more

physica status solidi (RRL) – Rapid Research Letters > 13 > 12 > n/a - n/a

Conventionally, wavelength‐selective ultraviolet photodetection is achieved by using broadband inorganic photodiodes coupled with optical filters, which significantly increases the complexity and fabricating cost of devices for high pixel density imaging systems. Here, a facile approach to achieve tunable spectral response without filters is demonstrated. The devices are based on ZnO heterojunctions,...

article

Lipoprotein receptor‐related protein 6 is required to maintain intercalated disk integrity

Xiang Wang, Yan Zou, Yang Li, Zhidan Chen, more

Genes to Cells > 24 > 12 > 789 - 800

The intercalated disk (ID), a highly organized adhesion structure connecting neighboring cardiomyocytes, fulfills mechanical and electrical signaling communication to ensure normal heart function. Lipoprotein receptor‐related protein 6 (LRP6) is a co‐receptor inducing canonical Wnt/β‐catenin signaling. It was recently reported that LRP6 deficiency in cardiomyocytes predisposes to arrhythmia independent...

article

Bilobalide alleviates IL‐17‐induced inflammatory injury in ATDC5 cells by downregulation of microRNA‐125a

Dongmei Mao, Hong Li, Lei Zhang, Jian Xu, more

Journal of Biochemical and Molecular Toxicology > 33 > 12 > n/a - n/a

Ankylosing spondylitis (AS) is a high disability and greatly destructive disease. In this study, we preliminarily studied the function and mechanism of bilobalide (BIL) on interleukin (IL)‐17‐induced inflammatory injury in ATDC5 cells. CCK‐8 and migration assays were used to detect the functions of IL‐7, BIL, and microRNA (miR)‐125a on cell viability and migration. The miR‐125a level was changed by...

article

Systematic review of endovascular repair of ascending aortic dissection

Lei Zhang, Zhenjiang Li, Shuangshuang Li, Zhiqing Zhao, more

Catheterization and Cardiovascular Interventions > 94 > 7 > 1018 - 1025

Background Endovascular repair has been used in selected ascending aortic dissection patients judged unfit for direct open surgery. However, the selective criteria and the results of endovascular repair of ascending aortic dissection, and the potential risk factors of adverse events were still obscure. The aim of this study was to summarize the published data linking endovascular therapy for ascending...

article

Detection and Chiral Recognition of α‐Hydroxyl Acid through ¹H and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex

Haonan He, Kelu Zhao, Long Xiao, Yi Zhang, more

Angewandte Chemie International Edition > 58 > 50 > 18286 - 18289

Chiral α‐hydroxyl acids are of great importance in chemical synthesis. Current methods for recognizing their chirality by ¹H NMR are limited by their small chemical shift differences and intrinsic solubility problem in organic solvents. Herein, we developed three YbDO3A(ala)₃ derivatives to recognize four different commercially available chiral α‐hydroxyl acids in aqueous solution through ¹H NMR and...

article

Detection and Chiral Recognition of α‐Hydroxyl Acid through ¹H and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex

Haonan He, Kelu Zhao, Long Xiao, Yi Zhang, more

Angewandte Chemie > 131 > 50 > 18454 - 18457

article

Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species

Ting Zhou, Xiujun Luo, Chengchao Zhang, Xinyun Xu, more

BMC Plant Biology > 2019 > 19 > 1 > 1-12

Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids and other active ingredients can vary greatly among Taxus species. In our study, the metabolomes of three Taxus species have been investigated. ...

article

Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease

Qinjun Zhao, Leisheng Zhang, Yimeng Wei, Hao Yu, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-14

Background Mesenchymal stem cells are heterogenous populations with hematopoietic supporting and immunomodulating capacities. Enormous studies have focused on their preclinical or clinical therapeutic effects, yet the systematic study of continuous in vitro passages on signatures and functions of UC-MSCs at both the cellular and molecular levels is still lacking. Methods In this study, to systematically...

article

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

Yilong Shan, Sha Tan, Yinyao Lin, Siyuan Liao, more

Journal of Neuroinflammation > 2019 > 16 > 1 > 1-20

Background Preserving the integrity of the blood-brain barrier (BBB) is beneficial to avoid further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component of the BBB, promote BBB breakdown in subjects with AIS by secreting inflammatory factors. The glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) protects the BBB and reduces brain inflammation from cerebral...

article

Silencing of keratin 1 inactivates the Notch signaling pathway to inhibit renal interstitial fibrosis and glomerular sclerosis in uremia

Wen Chen, Zhi‐Kui Wang, Yue‐Qin Ren, Lei Zhang, more

Journal of Cellular Physiology > 235 > 2 > 1674 - 1688

Renal interstitial fibrosis is a key factor in the development of chronic renal diseases, possibly leading to uremia. The present study conducted aimed to assess the hypothesis whether keratin 1 (KRT1) silencing could suppress kidney interstitial fibrosis and glomerular sclerosis via the Notch pathway to alleviate uremic symptoms. Differentially expressed genes associated with uremia were identified...

article

Identifying Copper Vacancies and Their Role in the CuO Based Photocathode for Water Splitting

Zhiliang Wang, Lei Zhang, Tobias U. Schülli, Yang Bai, more

Angewandte Chemie International Edition > 58 > 49 > 17604 - 17609

Metal oxides are an important family of semiconductors for effective photoelectrodes in solar‐to‐chemical energy conversion. Defect engineering, such as modification of oxygen vacancy density, has been extensively applied in tailoring the optoelectric properties of photoelectrodes. Very limited attention has been paid to the influence of metal vacancies. Herein, we study metal vacancies in a typical...

article

Identifying Copper Vacancies and Their Role in the CuO Based Photocathode for Water Splitting

Zhiliang Wang, Lei Zhang, Tobias U. Schülli, Yang Bai, more

Angewandte Chemie > 131 > 49 > 17768 - 17773

article

Two functional variants at 6p21.1 were associated with lean mass

Yu-Fang Pei, Wen-Zhu Hu, Xiao-Lin Yang, Xin-Tong Wei, more

Skeletal Muscle > 2019 > 9 > 1 > 1-10

Background Low lean body mass is the most important predictor of sarcopenia with strong genetic background. The aim of this study was to uncover genetic factors underlying lean mass development. Materials and methods We performed a genome-wide association study (GWAS) of fat-adjusted leg lean mass in the Framingham Heart Study (FHS, N = 6587), and replicated in the Women’s Health Initiative–African...

article

Reliable reconstruction of the complex high-location bile duct injury: a novel hepaticojejunostomy

Yuxin Zhang, Jianping Zhao, Songshan Chai, Zhanguo Zhang, more

BMC Surgery > 2019 > 19 > 1 > 1-7

Background This study aimed to propose a novel surgical reconstruction technique for complex high-location bile duct injury (CHBDI). Methods There were eight patients with CHBDI underwent the novel hepaticojejunostomy between Feb 2015 and Feb 2017. Seven patients underwent a primary operation and found CHBDI postoperatively in the inferior hospitals referred to our center. And four of them had received...

article

Molecular characterization and genetic diversity of Ornithonyssus sylviarum in chickens (Gallus gallus) from Hainan Island, China

Biswajit Bhowmick, Jianguo Zhao, Øivind Øines, Tianlin Bi, more

Parasites & Vectors > 2019 > 12 > 1 > 1-15

Background The northern fowl mite (NFM), Ornithonyssus sylviarum, is an obligatory hematophagous ectoparasite of birds and one of the most important pests in the poultry industry on several continents. Although NFM poses a serious problem, it remains a neglected pest of poultry in China and other Asian countries. Therefore, a molecular analysis was conducted to provide baseline information on the...

article

Transcriptomic analysis of Verbena bonariensis roots in response to cadmium stress

Meng-qi Wang, Zhen-yu Bai, Ya-fang Xiao, Yan Li, more

BMC Genomics > 2019 > 20 > 1 > 1-14

Background Cadmium (Cd) is a serious heavy metal (HM) soil pollutant. To alleviate or even eliminate HM pollution in soil, environmental-friendly methods are applied. One is that special plants are cultivated to absorb the HM in the contaminated soil. As an excellent economical plant with ornamental value and sound adaptability, V. bonariensis could be adapted to this very situation. In our study,...

article

Neurology practice and stroke services across East China: a multi-site, county-level hospital-based survey

Jun-Fang Zhang, Meng-Yao Qiu, Yu-Lei Zhang, Xi-Xi Wang, more

BMC Neurology > 2019 > 19 > 1 > 1-7

Background Neurological disorders are an economic and public health burden which requires efficient and adequate medical resources. Currently, little is known about the status of the quality of neurological care services available in China. As neurological primary care is mostly provided at the county hospital level, investigation of this geographical level is required. The aim of this study is to...

article

Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data

Fenglin Liu, Yuanyuan Zhang, Lei Zhang, Ziyi Li, more

Genome Biology > 2019 > 20 > 1 > 1-15

Background Systematic interrogation of single-nucleotide variants (SNVs) is one of the most promising approaches to delineate the cellular heterogeneity and phylogenetic relationships at the single-cell level. While SNV detection from abundant single-cell RNA sequencing (scRNA-seq) data is applicable and cost-effective in identifying expressed variants, inferring sub-clones, and deciphering genotype-phenotype...

article

Effect of oocyte vitrification on DNA damage in metaphase II oocytes and the resulting preimplantation embryos

Haoya Chang, Huanhuan Chen, Lei Zhang, Yile Wang, more

Molecular Reproduction and Development > 86 > 11 > 1603 - 1614

As an assisted reproduction technology, vitrification has been widely used for oocyte and embryo cryopreservation. Many studies have indicated that vitrification affects ultrastructure, gene expression, and epigenetic status. However, it is still controversial whether oocyte vitrification could induce DNA damage in metaphase II (MII) oocytes and the resulting early embryos. This study determined whether...

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INFONA - science communication portal

Search results for: Lei Zhang

Versatile and Highly Efficient Controls of Reversible Topotactic Metal–Insulator Transitions through Proton Intercalation

ZnO‐Based Ultraviolet Photodetectors with Tunable Spectral Responses

Lipoprotein receptor‐related protein 6 is required to maintain intercalated disk integrity

Bilobalide alleviates IL‐17‐induced inflammatory injury in ATDC5 cells by downregulation of microRNA‐125a

Systematic review of endovascular repair of ascending aortic dissection

Detection and Chiral Recognition of α‐Hydroxyl Acid through ¹H and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex

Detection and Chiral Recognition of α‐Hydroxyl Acid through ¹H and CEST NMR Spectroscopy Using a Ytterbium Macrocyclic Complex

Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species

Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

Silencing of keratin 1 inactivates the Notch signaling pathway to inhibit renal interstitial fibrosis and glomerular sclerosis in uremia

Identifying Copper Vacancies and Their Role in the CuO Based Photocathode for Water Splitting

Identifying Copper Vacancies and Their Role in the CuO Based Photocathode for Water Splitting

Two functional variants at 6p21.1 were associated with lean mass

Reliable reconstruction of the complex high-location bile duct injury: a novel hepaticojejunostomy

Molecular characterization and genetic diversity of Ornithonyssus sylviarum in chickens (Gallus gallus) from Hainan Island, China

Transcriptomic analysis of Verbena bonariensis roots in response to cadmium stress

Neurology practice and stroke services across East China: a multi-site, county-level hospital-based survey

Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data

Effect of oocyte vitrification on DNA damage in metaphase II oocytes and the resulting preimplantation embryos

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