Inflammation and overexpression of cyclooxygenase‐2 (COX‐2) have been described to play a key role in the progression from nonpathologic intestinal mucosa to colorectal cancer (CRC).
To assess the chemoprotective effect of non‐aspirin nonsteroidal anti‐inflammatory drugs (NA‐NSAIDs) under different patterns of use in a Mediterranean population and to explore the potential effect...
To define and validate a case‐finding algorithm to identify incident colorectal cancer (CRC) in the Spanish primary care database BIFAP.
All potential incident CRC cases recorded during the study period 2001 to 2014 among patients 20 to 89 years old were identified using a defined case‐finding algorithm tailored to BIFAP database characteristics and based on codes plus text mining...
Purpose To estimate the specific incidences of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among new users of drugs frequently reported to be associated with this serious event. Methods We performed a case-population approach, which combined data from a registry of SJS/TEN cases from the Madrid region (numerator) during the study period 2005–2015 and a primary healthcare database...
The “case‐population” design has been proposed for the surveillance of rare events like Stevens‐Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), wherein a registry of cases is combined with sales data from the source population in order to estimate crude odds ratios (ORs). A major drawback of this method is the inability to distinguish between new and non‐new users of drugs, which for...
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.