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Synaptically induced calcium transients in dendrites of Purkinje neurons (PNs) play a key role in the induction of plasticity in the cerebellar cortex (Ito, Physiol Rev 81:1143–1195, 2001). Long-term depression at parallel fiber–PN synapses can be induced by stimulation paradigms that are associated with long-lasting (>1 min) calcium signals. These signals remain strictly localized (Eilers et al...
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