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Three hydrophilic indocyanine dyes containing central 4-acetoxy-1,3-phenylene (O-acetyl-phenolic) moiety and 5-H, 5-sulfo and 5-methylencarboxylic substituents at both terminal indolenines were synthesized. Due to the π-conjugated system in these phenolo-cyanines being broken, these dyes absorb at shorter-wavelength region (∼400 nm) and have a negligible fluorescence. However, upon acetyl group cleavage...
Anticancer drugs connected to fluorescein based chemosensors by different biodegradable linkers were investigated for fluorescent monitoring in drug delivery models. The drug release triggered by chemo- and bio-hydrolytic environments was visualized on the basis of "switch on" fluorescence of the fluorophore moiety of fluorescein-drug conjugates. The conjugation of free phenolic hydroxyl...
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