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Urocortin (UCN) is a 40 amino acid peptide which is closely related to corticotropin-releasing hormone and binds with high affinity to both CRH type 1 and type 2 receptors. UCN is expressed in human reproductive tissues including endometrium, ovary, and placenta. This study was designed to investigate the cellular localization of UCN at the implantation site of the human blastocyst, as well as the...
The rapid development of the placenta necessitates a high proliferative potential and cell-division rate. This, coupled with a high capacity for invasion, could confer on the placental tissue a tumour-like character. To exclude this, tight mechanisms of control are necessary for both proliferation and invasiveness. Despite their importance, very little is known about the molecular basis of these mechanisms...
Glukokortikoide spielen eine entscheidende Rolle in der Aufrechterhaltung des homostatischen Gleichgewichts. Entsprechend ist ein vollstndiger Glukokortikoidmangel mit dem berleben des Organismus unvereinbar. Die Effekte von Glukokortikoiden werden ber den intrazellulr lokalisierten Glukokortikoidrezeptor (GR) bewirkt. GR ist ein ligandenabhngiger Transkriptionsfaktor, der in allen Geweben des menschlichen...
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