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The invertebrate glutamate-gated chloride channels (GluCls) are receptor molecules and targets for the avermectin–milbemycin (AM) group of anthelmintics. Mutations in GluCls are associated with ivermectin resistance in the soil dwelling nematode Caenorhabditis elegans and the parasitic nematode Cooperia oncophora. In this study, full-length cDNAs encoding α and β subunits of GluCl were cloned and...
We have monitored real-time alterations in [Ca 2+ ] i in fluo-3-loaded cerebellar granule neurons exposed to domoate, and ascertained the influence of pharmacological blockers of various Ca 2+ entry pathways on intracellular Ca 2+ accumulation, excitatory amino acid (EAA) release and neuronal death. Domoate produced a rapid and concentration-dependent...
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