Nathan K. Kaiser

article

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Chad R. Weisbrod, Nathan K. Kaiser, John E. P. Syka, Lee Early, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 9 > 1787-1795

High resolution mass spectrometry is a key technology for in-depth protein characterization. High-field Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) enables high-level interrogation of intact proteins in the most detail to date. However, an appropriate complement of fragmentation technologies must be paired with FTMS to provide comprehensive sequence coverage, as well as...

article

Improved ion optics for introduction of ions into a 9.4‐T Fourier transform ion cyclotron resonance mass spectrometer

Yu Chen, Franklin E. Leach, Nathan K. Kaiser, Xibei Dang, more

Journal of Mass Spectrometry > 50 > 1 > 280 - 284

Enhancements to the ion source and transfer optics of our 9.4 T Fourier transform ion cyclotron resonance (ICR) mass spectrometer have resulted in improved ion transmission efficiency for more sensitive mass measurement of complex mixtures at the MS and MS/MS levels. The tube lens/skimmer has been replaced by a dual ion funnel and the following octopole by a quadrupole for reduced ion cloud radial...

article

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Christopher L. Hendrickson, John P. Quinn, Nathan K. Kaiser, Donald F. Smith, more

Journal of The American Society for Mass Spectrometry > 2015 > 26 > 9 > 1626-1632

We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front...

article

Controlled Ion Ejection from an External Trap for Extended m/z Range in FT-ICR Mass Spectrometry

Nathan K. Kaiser, Joshua J. Savory, Christopher L. Hendrickson

Journal of The American Society for Mass Spectrometry > 2014 > 25 > 6 > 943-949

An auxiliary rf waveform of the same amplitude and phase applied to all the rods of an ion accumulation multipole creates an m/z-dependent axial pseudo potential. Controlled decrease of the auxiliary rf amplitude releases ions from the accumulation multipole sequentially from high to low m/z. The slope of the auxiliary rf voltage ramp is adjusted so that ions of different m/z reach the center of the...

article

Charge Reversal Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Vladislav V. Lobodin, Joshua J. Savory, Nathan K. Kaiser, Paul W. Dunk, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 2 > 213-221

We report the first charge reversal experiments performed by tandem-in-time rather than tandem-in-space MS/MS. Precursor odd-electron anions from fullerene C₆₀, and even-electron ions from 2,7-di-tert-butylfluorene-9-carboxylic acid and 3,3′-bicarbazole were converted into positive product ions (^–CR⁺) inside the magnet of a Fourier transform ion cyclotron resonance mass spectrometer. Charge reversal...

article

Formation of Heterofullerenes by Direct Exposure of C₆₀ to Boron Vapor

Paul W. Dunk, Antonio Rodríguez‐Fortea, Nathan K. Kaiser, Hisanori Shinohara, more

Angewandte Chemie > 125 > 1 > 333 - 337

Auf direktem Weg: Heterofullerene mit eingebautem Bor sind nur wenig erforscht, da keine Bildungsroute ausgehend von C₆₀ bekannt ist. Nun wurde gefunden, dass C₅₉B⁻, eine elektronisch geschlossenschalige Spezies, durch einfache Atomaustauschreaktionen aus unbehandeltem C₆₀ in der Gasphase gebildet wird.

article

Formation of Heterofullerenes by Direct Exposure of C₆₀ to Boron Vapor

Paul W. Dunk, Antonio Rodríguez‐Fortea, Nathan K. Kaiser, Hisanori Shinohara, more

Angewandte Chemie International Edition > 52 > 1 > 315 - 319

Introducing boron: Heterofullerenes that incorporate boron have been scarcely studied because a formation route from C₆₀ is not known. It is now reported that C₅₉B⁻, an electronically closed‐shell species, is formed directly from pristine C₆₀ in the gas‐phase by facile atom exchange reactions.

article

Unit Mass Baseline Resolution for an Intact 148 kDa Therapeutic Monoclonal Antibody by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Santosh G. Valeja, Nathan K. Kaiser, Feng Xian, Christopher L. Hendrickson, more

Analytical Chemistry > 2011 > 83 > 22 > 8391 - 8395

article

Electrically Compensated Fourier Transform Ion Cyclotron Resonance Cell for Complex Mixture Mass Analysis

Nathan K. Kaiser, Joshua J. Savory, Amy M. McKenna, John P. Quinn, more

Analytical Chemistry > 2011 > 83 > 17 > 6907 - 6910

article

Coulombic shielding during ion cyclotron excitation in FT-ICR mass spectrometry

Brian M. Ruddy, Steven C. Beu, Nathan K. Kaiser, Christopher L. Hendrickson, more

International Journal of Mass Spectrometry > 2011 > 301 > 1-3 > 220-223

Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry relies upon linearity between the ion cyclotron excitation and the observed response. However, nonlinearities result from non-ideal applied electric and magnetic fields and Coulombic interactions. Here, we report nonlinear response at low excitation electric field magnitude due to Coulombic shielding. The measured ICR signal magnitude...

article

Parts-Per-Billion Fourier Transform Ion Cyclotron Resonance Mass Measurement Accuracy with a “Walking” Calibration Equation

Joshua J. Savory, Nathan K. Kaiser, Amy M. McKenna, Feng Xian, more

Analytical Chemistry > 2011 > 83 > 5 > 1732 - 1736

article

A Novel 9.4 Tesla FTICR Mass Spectrometer with Improved Sensitivity, Mass Resolution, and Mass Range

Nathan K. Kaiser, John P. Quinn, Gregory T. Blakney, Christopher L. Hendrickson, more

Journal of The American Society for Mass Spectrometry > 2011 > 22 > 8 > 1343-1351

Fourier transform ion cyclotron resonance (FTICR) mass spectrometry provides unparalleled mass measurement accuracy and resolving power. However, propagation of the technique into new analytical fields requires continued advances in instrument speed and sensitivity. Here, we describe a substantial redesign of our custom-built 9.4 tesla FTICR mass spectrometer that improves sensitivity, acquisition...

article

Excite-Coupled Trapping Ring Electrode Cell (eTREC): Radial Trapping Field Control, Linearized Excitation, And Improved Detection

Chad R. Weisbrod, Nathan K. Kaiser, Gunnar E. Skulason, James E. Bruce

Analytical Chemistry > 2010 > 82 > 14 > 6281 - 6286

article

A Photocleavable and Mass Spectrometry Identifiable Cross-Linker for Protein Interaction Studies

Li Yang, Xiaoting Tang, Chad R. Weisbrod, Gerhard R. Munske, more

Analytical Chemistry > 2010 > 82 > 9 > 3556 - 3566

article

A Novel Fourier Transform Ion Cyclotron Resonance Mass Spectrometer with Improved Ion Trapping and Detection Capabilities

Nathan K. Kaiser, Gunnar E. Skulason, Chad R. Weisbrod, James E. Bruce

Journal of the American Society for Mass Spectrometry > 2009 > 20 > 5 > 755-762

A novel Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer has been developed for improved biomolecule analysis. A flared metal capillary and an electrodynamic ion funnel were installed in the source region of the instrument for improved ion transmission. The transfer quadrupole is divided into 19 segments, with the capacity for independent control of DC voltage biases for each segment...

article

A novel fourier transform ion cyclotron resonance mass spectrometer with improved ion trapping and detection capabilities

Nathan K. Kaiser, Gunnar E. Skulason, Chad R. Weisbrod, James E. Bruce

Journal of The American Society for Mass Spectrometry > 2009 > 20 > 5 > 755-762

A novel Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer has been developed for improved biomolecule analysis. A flared metal capillary and an electrodynamic ion funnel were installed in the source region of the instrument for improved ion transmission. The transfer quadrupole is divided into 19 segments, with the capacity for independent control of DC voltage biases for each segment...

article

Trapping Ring Electrode Cell: A FTICR Mass Spectrometer Cell for Improved Signal-to-Noise and Resolving Power

Chad R. Weisbrod, Nathan K. Kaiser, Gunnar E. Skulason, James E. Bruce

Analytical Chemistry > 2008 > 80 > 17 > 6545 - 6553

article

Reduction of Axial Kinetic Energy Induced Perturbations on Observed Cyclotron Frequency

Nathan K. Kaiser, Chad R. Weisbrod, Brian N. Webb, James E. Bruce

Journal of the American Society for Mass Spectrometry > 2008 > 19 > 4 > 467-478

With Fourier transform ion cyclotron resonance (FTICR) mass spectrometry one determines the mass-to-charge ratio of an ion by measuring its cyclotron frequency. However, the need to confine ions to the trapping region of the ion cyclotron resonance (ICR) cell with electric fields induces deviations from the unperturbed cyclotron frequency. Additional perturbations to the observed cyclotron frequency...

article

Reduction of axial kinetic energy induced perturbations on observed cyclotron frequency

Nathan K. Kaiser, Chad R. Weisbrod, Brian N. Webb, James E. Bruce

Journal of The American Society for Mass Spectrometry > 2008 > 19 > 4 > 467-478

With Fourier transform ion cyclotron resonance (FTICR) mass spectrometry one determines the mass-to-charge ratio of an ion by measuring its cyclotron frequency. However, the need to confine ions to the trapping region of the ion cyclotron resonance (ICR) cell with electric fields induces deviations from the unperturbed cyclotron frequency. Additional perturbations to the observed cyclotron frequency...

article

Reduction of ion magnetron motion and space charge using radial electric field modulation

Nathan K. Kaiser, James E. Bruce

International Journal of Mass Spectrometry > 2007 > 265 > 2-3 > 271-280

Ions of the same m/z must remain in phase with each other during the detection time period used for FTICR-MS signal acquisition for optimal performance. The loss of coherence of the ion cloud during detection leads to faster rates of signal decay which results in a decrease in the achievable resolution and mass measurement accuracy with FTICR-MS technology. As the ions spin on their excited cyclotron...

INFONA - science communication portal

Search results for: Nathan K. Kaiser

Front-End Electron Transfer Dissociation Coupled to a 21 Tesla FT-ICR Mass Spectrometer for Intact Protein Sequence Analysis

Improved ion optics for introduction of ions into a 9.4‐T Fourier transform ion cyclotron resonance mass spectrometer

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Controlled Ion Ejection from an External Trap for Extended m/z Range in FT-ICR Mass Spectrometry

Charge Reversal Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Formation of Heterofullerenes by Direct Exposure of C₆₀ to Boron Vapor

Formation of Heterofullerenes by Direct Exposure of C₆₀ to Boron Vapor

Unit Mass Baseline Resolution for an Intact 148 kDa Therapeutic Monoclonal Antibody by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Electrically Compensated Fourier Transform Ion Cyclotron Resonance Cell for Complex Mixture Mass Analysis

Coulombic shielding during ion cyclotron excitation in FT-ICR mass spectrometry

Parts-Per-Billion Fourier Transform Ion Cyclotron Resonance Mass Measurement Accuracy with a “Walking” Calibration Equation

A Novel 9.4 Tesla FTICR Mass Spectrometer with Improved Sensitivity, Mass Resolution, and Mass Range

Excite-Coupled Trapping Ring Electrode Cell (eTREC): Radial Trapping Field Control, Linearized Excitation, And Improved Detection

A Photocleavable and Mass Spectrometry Identifiable Cross-Linker for Protein Interaction Studies

A Novel Fourier Transform Ion Cyclotron Resonance Mass Spectrometer with Improved Ion Trapping and Detection Capabilities

A novel fourier transform ion cyclotron resonance mass spectrometer with improved ion trapping and detection capabilities

Trapping Ring Electrode Cell: A FTICR Mass Spectrometer Cell for Improved Signal-to-Noise and Resolving Power

Reduction of Axial Kinetic Energy Induced Perturbations on Observed Cyclotron Frequency

Reduction of axial kinetic energy induced perturbations on observed cyclotron frequency

Reduction of ion magnetron motion and space charge using radial electric field modulation

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Nathan K. Kaiser

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options