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Résumé Afin de définir les caractéristiques biomécaniques de la population issue de l’hypogée des Boileau, un ensemble funéraire collectif du Néolithique final vauclusien, nos travaux se sont orientés vers la géométrie de section. Cet outil permet d’estimer la capacité de l’os à résister à des contraintes mécaniques en mesurant les propriétés géométriques des sections transverses diaphysaires. Il...
The aim of the work was to analyze, on a comparative basis, the signaling pathways operating in the regulation of a panel of matrix metalloproteinases (MMP) expressed by human dermal fibroblasts submitted to mechanical stress relaxation by cytochalasin D (CD) and in a retracting collagen gel (RCG). The mRNA steady-state level of MMPs was measured by a quantitative RT-PCR procedure using a synthetic...
Mechanical tension governs fibroblast proliferation and survival and the homeostasis of the extracellular matrix to adapt its resistance to the mechanical requirements of the organs. To consolidate this view, we analysed the effect of tension release on the expression of molecules involved in the architecture and stabilisation of the collagen fibres, namely the procollagens type I and III, the amino-...
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