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Using high resolution multi-fluorescence microscopy, we herein report on the efficiency of the selective cyclooxygenase (C0X)-2 inhibitor parecoxib to improve compromised perfusion of traumatized skeletal muscle tissue and to prevent secondary tissue damage. Closed soft tissue trauma of the left hind limb was induced in pentobarbital-anesthetized rats that had received either parecoxib sodium (lOmg/kg...