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Background
Atopic dermatitis (AD) is associated with a dysregulation of the skin barrier and may predispose to the development of secondary allergic conditions, such as asthma. Tmem79ma/ma mice harbor a mutation in the gene encoding Transmembrane Protein 79 (or Mattrin), which has previously been associated with AD. As a result of the Tmem79 gene mutation, these mice have a defective skin barrier...
Background
Ambiguities exist regarding the diagnosis of tree‐nut allergy, necessitating either their elimination or the performance of oral food challenges (OFCs).
Objective
To examine the coincidences of allergies among tree‐nuts and improve diagnostic testing to minimize the need for OFC.
Methods
Eighty‐three patients prospectively evaluated for walnut, pecan, cashew, pistachio, hazelnut, and...
Background
Component‐resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity.
Aim
To analyze associations between severity and sensitization patterns, patient characteristics and clinical history, and to develop models to...
Asthma is responsible for approximately 25,000 deaths annually in Europe despite available medicines that maintain asthma control and reduce asthma exacerbations. Better treatments are urgently needed for the control of chronic asthma and reduction in asthma exacerbations, the major cause of asthma mortality. Much research spanning >20 years shows a strong association between microorganisms including...
The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives whilst ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study was to transfer innovation from an app developed by the MACVIA‐France EIP on AHA reference site (Allergy Diary) to other reference sites....
Background
Quality of life (QOL) is impaired in patients with food allergy and improves following oral immunotherapy (OIT). However, the treatment itself is prolonged and demanding. We examined changes in patient QOL during OIT for food allergy.
Methods
The FAQLQ‐PF was administered to children aged 4‐12 years undergoing OIT for milk, peanut, or egg allergy, at the beginning and after 4 months...
Background
Asthma is an allergic airway disease (AAD) caused by aberrant immune responses to allergens. Protein phosphatase‐2A (PP2A) is an abundant serine/threonine phosphatase with anti‐inflammatory activity. The ubiquitin proteasome system (UPS) controls many cellular processes, including the initiation of inflammatory responses by protein degradation. We assessed whether enhancing PP2A activity...
Background
There is a substantial body of evidence on the epidemiology of allergic conditions, which has advanced the understanding of these conditions. We aimed to systematically identify systematic reviews and meta‐analyses on the epidemiology of allergic diseases to assess what has been studied comprehensively and what areas might benefit from further research.
Methods
We searched PubMed and...
Background
Human rhinoviruses (HRVs) are one of the main causes of virus‐induced asthma exacerbations. Infiltration of B lymphocytes into the subepithelial tissue of the lungs has been demonstrated during rhinovirus infection in allergic individuals. However, the mechanisms through which HRVs modulate the immune responses of monocytes and lymphocytes are not yet well described.
Objective
To study...
Studies examining the long‐term effect of oral immunotherapy in food‐allergic patients are limited. We investigated cow's milk‐allergic patients, >6 months after the completion of oral immunotherapy (n = 197). Questionnaires, skin prick tests, and basophil activation assays were performed. Of the 195 patients contacted, 180 (92.3%) were consuming milk protein regularly. Half experienced adverse...
BackgroundHouse dust mite (HDM) acts on the airway epithelium to induce airway inflammation in asthma. We previously showed that the ability of HDM to induce allergic sensitization in mice is related to airway epithelial CCL20 secretion.
ObjectiveAs a disintegrin and metalloprotease (ADAM)s have been implicated in chemokine shedding, we sought to determine their involvement in HDM‐induced release...
Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK‐rhinitis (MACVIA‐ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred...
BackgroundEarly life farm exposures have been shown to decrease the risk of allergic diseases. Dendritic cells (DCs) may mediate asthma‐protective effect of farm exposures as they play an important role in the development of immunity and tolerance. Our aim was to investigate whether the numbers and phenotypes of circulating DCs at age 6 are associated with farming, asthma, and atopy in a selected...
BackgroundAsthma and other Th2 inflammatory conditions have been associated with increased susceptibility to viral infections. The mechanisms by which Th2 cytokines can influence immune responses to infections are largely unknown.
MethodsWe measured the effects of Th2 cytokines (IL‐4 and IL‐13) on bronchial epithelial cell innate immune antiviral responses by assessing interferon (IFN‐β and IFN‐λ1)...
BackgroundGastrointestinal nematodes are currently being evaluated as a novel therapeutic in the treatment of chronic human inflammatory disorders, due to their unique ability to induce immunoregulatory pathways in their hosts. In particular, administration of ova from the pig whipworm Trichuris suis (T. suis; TSO) has been proposed for the treatment of allergic, inflammatory and autoimmune disorders...
BackgroundHouse dust mite (HDM) affects the immunological and physical barrier function of airway epithelium, leading to allergic sensitization, airway remodeling, and eosinophilic inflammation in mouse models, although the mechanisms are still largely unknown.
ObjectiveGiven the implications for adenosine triphosphate (ATP)‐dependent Ca2+ signaling in allergic sensitization in mice, we sought to...
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