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Unser Verständnis für die molekularen Grundlagen von Krebs hat sich in den vergangenen Jahren umfassend vertieft. Dies ging mit der Entwicklung neuartiger zielgerichteter Medikamente einher, die zunehmende Erfolge bei der Behandlung von Krebs erreichen können. Zahlreiche klinische Studien prüfen den Nutzen der neuen Medikamente und gleichzeitig den Wert von gewebebasierten Biomarkern, die im Sinne...
In the last two decades, our knowledge about cancer genetics and cancer biology increased exponentially. Deep sequencing now allows rapid and cost-effective analysis of entire cancer genomes. Dysregulation of cell growth, cell survival, tissue homeostasis, and immune surveillance have been recognized as hallmarks of cancer. In parallel, diagnostic surgical pathology has been harmonized and consensus...
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