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Chitosan nanoparticles (NC) have excellent capacity for protein entrapment, favorable epithelial permeability, and are regarded as promising nanocarriers for oral protein delivery. Herein, we designed and evaluated a class of core shell corona nanolipoparticles (CSC) to further improve the absorption through enhanced intestinal mucus penetration. CSC contains chitosan nanoparticles as a core component...
ObjectiveThe aim of this study was to investigate Pluronic F127‐modified liposome‐containing cyclodextrin (CD) inclusion complex (FLIC) for improving the solubility, cellular uptake and intestinal penetration of tacrolimus (FK 506) in the gastrointestinal (GI) tract.
MethodsMolecular modelling was performed to screen the optimal CD for the solubilization of FK 506. FLIC was prepared by thin‐lipid...
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