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We report the use of digital signal processing (DSP) strategies to realize high-sensitivity on-chip fluorescence detection in microfluidic-opto-electronic printed circuit board (PCB) devices without requiring bulky high-quality optical components and filters. An isotachophoresis (ITP) assay was studied in a microfluidic PCB with an embedded standard complementary metal oxide semiconductor sensor array...
We present a novel packaging architecture for fluidic surface mount components in microfluidic printed circuit boards (PCB)s. The package incorporates sacrificial layers to protect the fluid cavities and inlets/outlets to the component during mounting and integration on a microfluidic circuit board. In this paper we describe the general scheme to package and integrate microfluidic components such...
We have developed a novel bioflexible electronic device, called “Bioflexible ITP Chip” that integrates Isotachophoresis for biochemical analysis of blood on flexible and conformable circuitry and packaging. The device demonstrates scalable integration and fabrication technologies that are borrowed from the packaging and PCB industry and applied to wearable medical applications. This work demonstrates...
We have developed a novel process that uses Ethylene-Vinyl Acetate (EVA) films to realize low cost integrated microfluidic systems in small packages. The EVA acts as both a final package for the device as well as a functional material for hosting molded microfluidic channels and optical structures such as waveguides. In this paper we describe the lamination based packaging of microfluidics, characterize...
Modern semiconductor chips are reaching higher power densities, requiring cooling capacities in excess of 100 W/cm2. Liquid cooling is widely seen as the appropriate technology to provide cooling for these devices, however, convenient, integrated cooling techniques are not available. We report the use of a chip cooling package designed to interface directly with an embedded fluidic system that routes...
We report the development of a packaged thermal component with integrated sensor for use in integrated microfluidic systems that need to accurately and conveniently control fluid temperature in one or more microfluidic reservoirs. The small surface mounted component can be assembled on a circuit board and encapsulated in biocompatible polymer for use as part of a “lab-on-a-chip” system. Such systems...
Recent advancement in the printed circuit board (PCB) industry has enabled the production of highly sophisticated electronic substrates at high-resolution and low production cost. These boards make an ideal platform for producing microfluidic devices for lab-on-a-chip and point-of-care applications, since such devices require a high degree of integration, something that is critically lacking in current...
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