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Neuronal nitric oxide synthase (nNOS) is important in cardiac protection in diseased heart. Recently, we have reported that nNOS is associated with myofilament Ca2+ desensitization in cardiac myocytes from hypertensive rats. So far, the effect of myofilament Ca2+ desensitization or nNOS on L-type Ca2+ channel activity (ICa) in cardiac myocyte is unclear. Here, we examined nNOS regulation of ICa in...
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