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Background & Aims: We investigated whether endothelial progenitor cell (EPC) transplantation could reduce established liver fibrosis and promote hepatic regeneration by isolating rat EPCs from bone marrow cells. Methods: Recipient rats were injected intraperitoneally with carbon tetrachloride (CCl 4 ) twice weekly for 6 weeks before initial administration of EPCs. CCl 4 was then...
Background & Aims: Recent studies indicate that kringle 1–5 has a potent and specific antiangiogenic activity. Here, we investigated the antitumor effect of kringle 1–5 gene transfer on hepatocellular carcinoma in mice. Methods: The inhibitory effect of kringle 1–5 protein on proliferation of bovine capillary endothelial cells was evaluated by a tetrazolium-based assay. To study tumor growth,...
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