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Alterations in the brain of rats receiving a single non-convulsive administration pentylenetetrazol (PTZ), 30 mg/kg, i.p. (single PTZ group) were investigated and compared with those detected in fully PTZ kindled rats (chronic PTZ group). In vitro receptor autoradiography experiments showed that both single and chronic PTZ groups presented reduced mu opioid and benzodiazepine (BDZ) receptor binding...
Benzodiazepine (BDZ) receptor-binding changes in the rat brain induced by pentylentetrazol (PTZ) were investigated by in vitro autoradiography. Our experiments revealed that a single PTZ administration produced BDZ-binding decrease in cingulate, frontal, temporal, parietal and piriform cortices; caudate putamen; medial, basolateral and cortical amygdaloid nuclei; medial, ventromedial and ventroposterior...
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