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Antibodies (Abs) that mediate the hyperacute rejection and acute vascular rejection/delayed xenograft rejection of pig organs in humans and Old World primates are predominantly directed at a single carbohydrate epitope, galactose-α1,3-galactose (α1,3Gal). The T-cell dependence of elicited anti-α1,3Gal Ab responses in humans and Old World primates is controversial. In this study we have characterized...
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