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Zebrafish and newt heart regeneration has been demonstrated to be the result of cardiomyocyte proliferation, which has suggested the feasibility of maintaining the proliferation capacity of native mammalian neonatal cardiomyocytes. Recent experiments demonstrating that stem cells are highly depolarized while terminally differentiated cells are hyperpolarized have indicated a potential role of membrane...
Cardiomyocytes (CMs) undergo a rapid transition from hyperplastic to hypertrophic growth soon after birth, which is a major challenge to the development of engineered cardiac tissue for pediatric patients. Resting membrane potential (Vmem) has been shown to play an important role in cell differentiation and proliferation during development. We hypothesized that depolarization of neonatal CMs would...
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