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Natural compounds found in mangosteen peel such as squalene and α-cubebene were proven to exhibit antimicrobial, antibacterial and anticancer activity for cancer disease treatment. Supercritical Carbon Dioxide (SC-CO2) extraction process was conducted at constant flowrate of 24 mL/min within 40 minutes and by varying temperature and pressure from 50 to 80°C and from 34.5 to 55.1 MPa, respectively...