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We previously reported that conventional protein kinase C (cPKC)β participated in hypoxic preconditioning‐induced neuroprotection against cerebral ischemic injury, and collapsin response‐mediated protein 2 (CRMP2) was identified as a cPKCβ interacting protein. In this study, we explored the regulation of CRMP2 phosphorylation and proteolysis by cPKCβ, and their role in ischemic injury of oxygen–glucose...
To investigate the association between interleukin-6 (IL-6) −174G>C and −572C>G polymorphisms and risk for ischemic stroke (IS) in young patients.We genotyped IL-6 −174G>C and −572C>G in a case–control study of 430 young IS patients and 461 control subjects. An unconditional multiple logistical regression model was used to calculate the effects of IL-6−174G>C and −572C>G polymorphisms...
The understanding of molecular mechanism underlying ischemia/reperfusion-induced neuronal death and neurological dysfunction may provide therapeutic targets for ischemic stroke. The up-regulated miRNA-30a among our previous identified 19 MicroRNAs (miRNAs) in mouse brain after 6 h middle cerebral artery occlusion (MCAO) could negatively regulate Beclin 1 messenger RNA (mRNA) resulting in decreased...
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