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Aim: AS1535907, a small molecule agonist of GPR119, was assessed for its glucose‐stimulated insulin secretory activity and pancreatic β‐cell function in type 2 diabetes.
Methods: Both in vitro and in vivo tests were conducted using NIT‐1 and HEK293 cell lines, male normal and db/db mice and isolated perfused rat pancreas preparations.
Results: AS1535907 had an EC50 value of 1.5 µM for human GPR119...
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