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Although Alzheimer's disease (AD) is a primary degenerative disorder, a microglial-mediated inflammatory response, provoked by amyloid β (Aβ), contributes to the neurodegeneration and subsequently to the cell loss. Since such an inflammatory contribution to neurodegeneration may influence disease progression, a basic question arises concerning the mechanisms of possible clinical signs dependent on...
Recent data have shown that in the early stages of Alzheimer’s disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage.Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging, were analyzed retrospectively in 72 patients with early and late onset sporadic AD.All types of ischemic lesions occurred...
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