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The complement-inhibitory activities of the membrane complement regulators, decay accelerating factor (DAF), membrane cofactor protein (MCP), CD59 and complement receptor 1 (CR1), and their role in protection of “self” from the damaging effects of complement have long been understood. In recent years it has become clear that these proteins have additional roles and functions in health and disease...
The complement-inhibitory activities of the membrane complement regulators, decay accelerating factor (DAF), membrane cofactor protein (MCP), CD59 and complement receptor 1 (CR1), and their role in protection of “self” from the damaging effects of complement have long been understood. In recent years it has become clear that these proteins have additional roles and functions in health and disease...
Despite its vital role in innate immunity, complement is involved in a number of inflammatory pathologies and has therefore become a therapeutic target. Most agents generated for anti-complement therapy have short half-lives in plasma, or have been of mouse or human origin, thereby limiting their use either to murine models of disease or to short-term therapy. Here we describe the generation of a...
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