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Male Sprague-Dawley rats received injections of 100 or 375 ng 192-IgG saporin (SAP) or artificial CSF (C) into the medial septum/diagonal band complex (MSDB). SAP treated rats exhibited brief increases in daily water consumption which recovered to control levels by twenty one days following surgical treatment. Half of all subjects were preexposed to a 0.2% saccharin solution (CS) for 4 consecutive...
192-IgG-Saporin is an anti-neuronal immunotoxin that combines the 192 monoclonal antibody to the p75 neurotrophin receptor found on terminals and cell bodies of neurons in the cholinergic basal forebrain with the ribosome-inactivating protein saporin. Bilateral intraventricular injection of the 192-saporin produced a variety of dose-related behavioral, neurochemical, and histological alterations in...
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