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With aging population, increase in longevity and decrease in the number of qualified donors, the need to find alternative solutions to current organ replacement methods is rapidly becoming a critical issue. Tissue engineering has appeared as a potentially viable solution. Classical tissue engineering is based on culturing cells in scaffolds, artificial extracellular matrix mimics, with the hope that...
Impairment of tissue cohesion and the reorganization of the extracellular matrix are crucial events during the progression toward invasive cell phenotype. We studied the in vitro invasion patterns of nine brain tumor cell lines in three-dimensional collagen gels. Cell-cell and cell-matrix interactions were quantified and correlated with the expression level of specific molecules: N-cadherin, matrix...
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