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Morphogenesis of the heart requires development of the endocardial cushion tissue that gives rise to the membranous septa and valves. Here we show that Meltrin β/ADAM19, a novel metalloprotease-disintegrin, participates in the development of the endocardial cushion. Mice lacking Meltrin β exhibit ventricular septal defect (VSD) and immature valves, and most of the animals die soon after birth. During...
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