Search results for: Audrey R. Tyrka

Items from 1 to 20 out of 47 results

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Feasibility of Computerized Cognitive‐Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression

Emma S. Welch, Anne Weigand, Julia E. Hooker, Noah S. Philip, more

Neuromodulation: Technology at the Neural Interface > 22 > 8 > 898 - 903

Background Cognitive behavioral therapy (CBT) is effective in the treatment of major depressive disorder (MDD). Transcranial Direct Current Stimulation (tDCS) has demonstrated preliminary antidepressant effects and beneficial effects on cognitive function. Objective We investigated the feasibility and acceptability of using tDCS to enhance the effects of computer‐based CBT for treatment of MDD...

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Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder

Noah S. Philip, Jennifer Barredo, Mascha van ’t Wout-Frank, Audrey R. Tyrka, more

Biological Psychiatry > 2018 > 83 > 3 > 263-272

Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study to evaluate TMS-associated changes in connectivity in patients with comorbid posttraumatic...

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Response to Letter to the Editor regarding “Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic outcomes for younger versus older patients”

Christine A. Conelea, Noah S. Philip, Augustin G. Yip, Jennifer L. Barnes, more

Journal of Affective Disorders > 2018 > 225 > C > 773-774

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Heart Rate Variability Responses to a Standardized Virtual Reality Exposure in Veterans with PTSD

Samuel J. Ridout, Christopher M. Spofford, Mascha Wout-Frank, Noah S. Philip, more

Current Treatment Options in Psychiatry > 2017 > 4 > 3 > 271-280

Opinion Statement Purpose In this article, we present data incorporating heart rate variability (HRV) into a graded virtual reality protocol performed in both a combat environment and an active control (classroom) environment, for combat Veterans with and without PTSD.Recent Findings Exposure therapy for PTSD has proven effective. There is increasing interest in the use of virtual reality exposure...

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Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic treatment outcomes for younger versus older patients

Christine A. Conelea, Noah S. Philip, Agustin G. Yip, Jennifer L. Barnes, more

Journal of Affective Disorders > 2017 > 217 > C > 42-47

Repetitive transcranial magnetic stimulation (TMS) has been shown to be safe and effective for treatment-resistant depression (TRD) in the general adult population. Efficacy among older (≥60 years) patients, who have a greater burden of cognitive, physical, and functional impairment compared to their younger counterparts, remains unclear. The current study aimed to characterize antidepressant response...

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Crack cocaine addiction, early life stress and accelerated cellular aging among women

Mateus Luz Levandowski, Saulo Gantes Tractenberg, Lucas Araújo de Azeredo, Tatiana De Nardi, more

Progress in Neuro-Psychopharmacology and Biological Psychiatry > 2016 > 71 > C > 83-89

Early life stress (ELS) and addiction are related to age-related diseases and telomere shortening. However, the role of telomere length (TL) in crack cocaine addiction remains unknown. The purpose of this study was to investigate the TL in a sample of crack cocaine dependent-women who reported an ELS history and in a community-based sample of elderly women as a reference group for senescence.This...

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5.2 ASSOCIATION BETWEEN MOLECULAR MARKERS OF NEUROENDOCRINE FUNCTION AND CELLULAR METABOLISM WITH EARLY LIFE STRESS AND PSYCHOPATHOLOGY

Kathryn K. Ridout, Stephanie H. Parade, Linda L. Carpenter, Lawrence H. Price, more

Journal of the American Academy of Child & Adolescent Psychiatry > 2016 > 55 > 10(S) > S184

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Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity

Noah S. Philip, Audrey R. Tyrka, Sarah E. Albright, Lawrence H. Sweet, more

Journal of Psychiatric Research > 2016 > 79 > C > 93-100

Early life stress (ELS) is an established risk factor for psychiatric illness and is associated with altered functional connectivity within- and between intrinsic neural networks. The widespread nature of these disruptions suggests that broad imaging measures of neural connectivity, such as global based connectivity (GBC), may be particularly appropriate for studies of this population. GBC is designed...

article

Depression and telomere length: A meta-analysis

Kathryn K. Ridout, Samuel J. Ridout, Lawrence H. Price, Srijan Sen, more

Journal of Affective Disorders > 2016 > 191 > C > 237-247

Several recent studies have investigated the relationship between telomere length and depression with inconsistent results. This meta-analysis examined whether telomere length and depression are associated and explored factors that might affect this association.Studies measuring telomere length in subjects with clinically significant unipolar depression were included. A comprehensive search strategy...

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Methylation of the Glucocorticoid Receptor Gene Promoter in Preschoolers: Links With Internalizing Behavior Problems

Stephanie H. Parade, Kathryn K. Ridout, Ronald Seifer, David A. Armstrong, more

Child Development > 87 > 1 > 86 - 97

Accumulating evidence suggests that early adversity is linked to methylation of the glucocorticoid receptor (GR) gene, NR3C1, which is a key regulator of the hypothalamic–pituitary–adrenal axis. Yet no prior work has considered the contribution of methylation of NR3C1 to emerging behavior problems and psychopathology in childhood. This study examined the links between methylation of NR3C1 and behavior...

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Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Audrey R. Tyrka, Stephanie H. Parade, Lawrence H. Price, Hung-Teh Kao, more

Biological Psychiatry > 2016 > 79 > 2 > 78-86

Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation...

article

Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task

Noah S. Philip, Lawrence H. Sweet, Audrey R. Tyrka, S. Louisa Carpenter, more

Brain Imaging and Behavior > 2016 > 10 > 1 > 124-135

Previous research suggests that a history of early life stress (ELS) impacts working memory (WM) in adulthood. Despite the widespread use of WM paradigms, few studies have evaluated whether ELS exposure, in the absence of psychiatric illness, also impacts WM-associated brain activity in ways that might improve sensitivity to these ELS effects or provide insights into the mechanisms of these effects...

article

The role of cytokines in the pathophysiology of suicidal behavior

Licínia Ganança, Maria A. Oquendo, Audrey R. Tyrka, Sebastian Cisneros-Trujillo, more

Psychoneuroendocrinology > 2016 > 63 > C > 296-310

Immune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects...

article

5Hz Repetitive transcranial magnetic stimulation to left prefrontal cortex for major depression

Noah S. Philip, S. Louisa Carpenter, Samuel J. Ridout, George Sanchez, more

Journal of Affective Disorders > 2015 > 186 > Complete > 13-17

Repetitive transcranial magnetic stimulation (rTMS) to left prefrontal cortex at 10Hz is the most commonly utilized protocol for major depressive disorder (MDD). Published data suggests that left sided 5Hz rTMS may be efficacious and well tolerated.We analyzed outcomes in a naturalistic cohort of MDD patients who could not tolerate 10Hz rTMS and were routinely switched to 5Hz. We hypothesized that...

article

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression

Darin D. Dougherty, Ali R. Rezai, Linda L. Carpenter, Robert H. Howland, more

Biological Psychiatry > 2015 > 78 > 4 > 240-248

Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral capsule/ventral striatum target, have shown encouraging response rates. However, no randomized controlled trials of DBS for TRD have been published.Thirty patients with TRD participated in a sham-controlled trial of DBS at the ventral capsule/ventral striatum target...

article

The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children

Joan Kaufman, Joel Gelernter, James J. Hudziak, Audrey R. Tyrka, more

Journal of the American Academy of Child & Adolescent Psychiatry > 2015 > 54 > 8 > 617-625

The Research Domain Criteria (RDoC) project was initiated to develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures. This article reviews the rationale behind the RDoC program, its goals, and central tenets; discusses application of an RDoC framework to research with maltreated children; and highlights some clinical...

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Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Audrey R. Tyrka, Linda L. Carpenter, Hung-Teh Kao, Barbara Porton, more

Experimental Gerontology > 2015 > 66 > Complete > 17-20

Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The present study examined the association between mitochondrial DNA (mtDNA) copy number...

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Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: Informing future studies of antidepressant treatments

Noah S. Philip, Thomas R. Valentine, Lawrence H. Sweet, Audrey R. Tyrka, more

Journal of Psychiatric Research > 2014 > 52 > Complete > 63-69

Exposure to early life stress (ELS) is strongly associated with poor treatment outcomes, particularly for trauma-associated disorders such as depression. Little research to date, however, has examined the potential effects of ELS on outcomes with newer treatments, such as repetitive transcranial magnetic stimulation (rTMS). This study evaluated whether ELS exposure impacts resting state functional...

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Risk factors for post-deployment posttraumatic stress disorder in national guard/reserve service members

M. Tracie Shea, Madhavi K. Reddy, Audrey R. Tyrka, Elizabeth Sevin

Psychiatry Research > 2013 > 210 > 3 > 1042-1048

Identification of factors that increase risk for PTSD in military personnel following deployments is critical to early intervention and prevention. The study tested hypothesized main and moderating risk factors for PTSD in National Guard/Reserve members deployed to Iraq or Afghanistan. Members of the National Guard/Reserves (n=238) completed diagnostic interviews and measures of risk factors at a...

article

Regional homogeneity and resting state functional connectivity: Associations with exposure to early life stress

Noah S. Philip, Yuliya I. Kuras, Thomas R. Valentine, Lawrence H. Sweet, more

Psychiatry Research: Neuroimaging > 2013 > 214 > 3 > 247-253

Early life stress (ELS) confers risk for psychiatric illness. Previous literature suggests ELS is associated with decreased resting-state functional connectivity (rs-FC) in adulthood, but there are no studies of resting-state neuronal activity in this population. This study investigated whether ELS-exposed individuals demonstrate resting-state activity patterns similar to those found in PTSD. Twenty-seven...

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Search results for: Audrey R. Tyrka

Feasibility of Computerized Cognitive‐Behavioral Therapy Combined With Bifrontal Transcranial Direct Current Stimulation for Treatment of Major Depression

Network Mechanisms of Clinical Response to Transcranial Magnetic Stimulation in Posttraumatic Stress Disorder and Major Depressive Disorder

Response to Letter to the Editor regarding “Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic outcomes for younger versus older patients”

Heart Rate Variability Responses to a Standardized Virtual Reality Exposure in Veterans with PTSD

Transcranial magnetic stimulation for treatment-resistant depression: Naturalistic treatment outcomes for younger versus older patients

Crack cocaine addiction, early life stress and accelerated cellular aging among women

5.2 ASSOCIATION BETWEEN MOLECULAR MARKERS OF NEUROENDOCRINE FUNCTION AND CELLULAR METABOLISM WITH EARLY LIFE STRESS AND PSYCHOPATHOLOGY

Early life stress predicts thalamic hyperconnectivity: A transdiagnostic study of global connectivity

Depression and telomere length: A meta-analysis

Methylation of the Glucocorticoid Receptor Gene Promoter in Preschoolers: Links With Internalizing Behavior Problems

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task

The role of cytokines in the pathophysiology of suicidal behavior

5Hz Repetitive transcranial magnetic stimulation to left prefrontal cortex for major depression

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression

The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: Informing future studies of antidepressant treatments

Risk factors for post-deployment posttraumatic stress disorder in national guard/reserve service members

Regional homogeneity and resting state functional connectivity: Associations with exposure to early life stress

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