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In the prostate testosterone is converted to dihydrotestosterone (DHT) by the enzymes 5α-reductase (5αR) types 1 and 2 (5αR1 and 5αR2). Suppression of DHT formation by 5αR inhibition may be beneficial in early treatment or prevention of prostate cancer. Although 5αR2 is the dominant enzyme in the prostate, evidence indicates that 5αR1 may be up-regulated in some prostate cancers. This suggests that...
Objectives. To evaluate prostate cancer detection and prostate-specific antigen (PSA) among men with benign prostatic hyperplasia treated with finasteride.Methods. Three thousand forty men 45 to 78 years of age with PSA less than 10 ng/mL and no history of prostate cancer were randomized in a double-blind, placebo-controlled trial to finasteride (n = 1524) or placebo (n = 1516) for up to 4 years....
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