Search results for: Dean K. Clodfelter

Items from 1 to 4 out of 4 results

article

Corrigendum to “(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine–[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors” [Bioorg. Med. Chem. Lett. 15 (2005) 349]

William J. Wheeler, Dean K. Clodfelter, Ivan Collado, Palaniappan Kulanthaivel, more

Bioorganic & Medicinal Chemistry Letters > 2005 > 15 > 4 > 1261

article

(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors

William J. Wheeler, Dean K. Clodfelter, Palaniappan Kulanthaivel, Concepcion Pedregal, more

Bioorganic & Medicinal Chemistry Letters > 2005 > 15 > 2 > 349-351

We report herein the synthesis of the tritium labeled isotopomer of 1 and its use as a radioligand to label mGlu8 receptors in rat forebrain membranes as well as cloned human recombinant mGlu receptors. [ ³ H]-1 was synthesized by the NaBT ₄ reduction of an activated analog of 5. [ ³ H]-1 bound appreciably to recombinant human mGlu2, mGlu3 and mGlu8 receptors and to rat forebrain...

article

Comparison of free solution capillary electrophoresis and size exclusion chromatography for quantitating non-covalent aggregation of an acylated peptide

Dean K. Clodfelter, Mark A. Nussbaum, John Reilly

Journal of Pharmaceutical and Biomedical Analysis > 1999 > 19 > 5 > 763 - 775

There are few methods available for the rapid and precise quantitation of non-covalent aggregation. The very methods used to measure the aggregation can easily disrupt the weak forces holding an aggregate together. This paper describes the novel application of free solution capillary electrophoresis (CE) for the quantitation of a biologically inactive non-covalent aggregate of C8GLIP (Des-amino-histidine-7-arginine-26...

article

Effects of Non-Covalent Self-Association on the Subcutaneous Absorption of a Therapeutic Peptide

Dean K. Clodfelter, Allen H. Pekar, Dawn M. Rebhun, Kevin A. Destrampe, more

Pharmaceutical Research > 1998 > 15 > 2 > 254-262

Purpose . To utilize an acylated peptide as a model system to investigate the relationships among solution peptide conformation, non-covalent self-association, subcutaneous absorption and bioavailability under pharmaceutically relevant solution formulation conditions. Methods . CD spectroscopy, FTIR spectroscopy, equilibrium sedimentation, dynamic light scattering, and size exclusion chromatography...

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Search results for: Dean K. Clodfelter

Corrigendum to “(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine–[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors” [Bioorg. Med. Chem. Lett. 15 (2005) 349]

(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors

Comparison of free solution capillary electrophoresis and size exclusion chromatography for quantitating non-covalent aggregation of an acylated peptide

Effects of Non-Covalent Self-Association on the Subcutaneous Absorption of a Therapeutic Peptide

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INFONA - science communication portal

Search results for: Dean K. Clodfelter

Corrigendum to “(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine–[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors” [Bioorg. Med. Chem. Lett. 15 (2005) 349]

(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors

Comparison of free solution capillary electrophoresis and size exclusion chromatography for quantitating non-covalent aggregation of an acylated peptide

Effects of Non-Covalent Self-Association on the Subcutaneous Absorption of a Therapeutic Peptide

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