Search results for: Hanna Piotrowska

Items from 1 to 19 out of 19 results

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The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, more

Investigational New Drugs > 2019 > 37 > 5 > 849-864

Summary It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound...

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Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors

Miłosz Regulski, Hanna Piotrowska-Kempisty, Wiesław Prukała, Zbigniew Dutkiewicz, more

Bioorganic & Medicinal Chemistry > 2018 > 26 > 1 > 141-151

25 new trans-stilbene and trans-stilbazole derivatives were investigated using in vitro and in silico techniques. The selectivity and potency of the compounds were assessed using commercial ELISA test. The obtained results were incorporated into 2D QSAR assay. The most promising compound 4-nitro-3′,4′,5′-trihydroxy-trans-stilbene (N1) was synthetized and its potency and selectivity were confirmed...

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Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Agnieszka Klupczynska, Anna Maria Sulej-Suchomska, Hanna Piotrowska-Kempisty, Marcin Wierzchowski, more

Journal of Chromatography B > 2017 > 1060 > C > 30-35

The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determination...

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Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

article

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells

Malgorzata Kucinska, Hanna Piotrowska-Kempisty, Natalia Lisiak, Mariusz Kaczmarek, more

Toxicology in Vitro > 2016 > 37 > C > 148-161

Previously, it has been reported that molecules built on the benzanilide and thiobenzanilide scaffold are the promising groups of compounds with several biological activities including antifungal, antimycotic, antibacterial, spasmolytic, and anticancer ones. In this study the mechanism of action of one selected thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63T) with...

article

COX-2 inhibitors: a novel strategy in the management of breast cancer

Miłosz Regulski, Katarzyna Regulska, Wiesław Prukała, Hanna Piotrowska, more

Drug Discovery Today > 2016 > 21 > 4 > 598-615

Cyclooxygenase-2 (COX-2) inhibitors are common anti-inflammatory drugs with pleiotropic, endogenous actions that could be useful in the management of breast cancer. Here, we provide a complete understanding of the biochemistry of COX-2 and discuss the various molecular mechanisms behind its increased expression in breast cancer. We also analyze the possible mechanisms responsible for the anticancer...

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The radiolytic studies of cefpirome sulfate in the solid state

Przemysław Zalewski, Robert Skibiński, Daria Szymanowska-Powałowska, Hanna Piotrowska, more

Journal of Pharmaceutical and Biomedical Analysis > 2016 > 118 > C > 410-416

The possibility of applying radiation sterilization to cefpirome sulfate was investigated. The lack of changes in the chemical structure of cefpirome sulfate irradiated with a dose of 25kGy, required to attain sterility, was confirmed by UV, FT-IR, Raman, DSC and chromatographic methods. Some radical defects with concentration no more than over a several dozen ppm were created by radiation. The antibacterial...

article

Synthesis and characterization of SBA-16 type mesoporous materials containing amine groups

Agnieszka Feliczak-Guzik, Barbara Jadach, Hanna Piotrowska, Marek Murias, more

Microporous and Mesoporous Materials > 2016 > 220 > C > 231-238

This work describes the synthesis of SBA-16 modified with amine groups and chitosan. The synthesized materials were characterized by small angle XRD (SXRD), wide angle XRD (WXRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier-transformed Infra-red (FTIR) spectroscopy and nitrogen adsorption/desorption techniques. The characterization results revealed that the...

article

Senescent peritoneal mesothelium induces a pro-angiogenic phenotype in ovarian cancer cells in vitro and in a mouse xenograft model in vivo

Justyna Mikuła-Pietrasik, Patrycja Sosińska, Eryk Naumowicz, Konstantin Maksin, more

Clinical & Experimental Metastasis > 2016 > 33 > 1 > 15-27

It is believed that senescent cells contribute to the progression of primary and metastatic tumors, however, the exact mechanisms of this activity remain elusive. In this report we show that senescent human peritoneal mesothelial cells (HPMCs) alter the secretory profile of ovarian cancer cells (A2780, OVCAR-3, SKOV-3) by increasing the release of four angiogenic agents: CXCL1, CXCL8, HGF, and VEGF...

article

DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer

Hanna Piotrowska, Krzysztof Myszkowski, Joanna Abraszek, Eliza Kwiatkowska-Borowczyk, more

Biomedicine & Pharmacotherapy > 2014 > 68 > 4 > 397-400

DMU-212 has been shown to evoke a mitochondrial apoptotic pathway in transformed fibroblasts and breast cancer. However, recently published data indicated the ability of DMU-212 to evoke apoptosis in both mitochondria- and receptor-mediated manner in two ovarian cancer cell lines, namely A-2780 and SKOV-3, which showed varied sensitivity to the compound tested. The pronounced cytotoxic effects of...

article

Prooxidative potential of hydroxylated resveratrol analogs

Malgorzata Kucinska, Hanna Piotrowska, Michał W. Luczak, Justyna Mikula-Pietrasik, more

Chemico-Biological Interactions > 2014 > 209 > Complete > 96-110

Resveratrol and its higher hydroxylated analogs have been reported to possess a variety of biological properties including antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable these compounds to protect cells from oxidative damage, however prooxidant activity are held likely to be responsible for their cytotoxic or pro-apoptotic effects. In present study the...

article

Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue

Hanna Piotrowska, Krzysztof Myszkowski, Ryszard Amarowicz, Marek Murias, more

Toxicology in Vitro > 2013 > 27 > 8 > 2127-2134

The cytotoxic activity of DMU-212 has been shown to vary in cell lines derived from the same type of cancer, i.e. ovarian, breast and colorectal ones. However, the molecular mechanism of DMU-212 cytotoxicity has not been clarified in colon cancer cells. This study aims to elucidate the mechanism of antitumor effects of DMU-212 in two human colon cancer cell lines, DLD-1 and LOVO. We showed the stronger...

article

Real-time proliferation of porcine cumulus cells is related to the protein levels and cellular distribution of Cdk4 and Cx43

Bartosz Kempisty, Agnieszka Ziółkowska, Hanna Piotrowska, Piotr Zawierucha, more

Theriogenology > 2013 > 80 > 4 > 411-420

The proper maturation of cumulus somatic cells depends on bidirectional communication between the oocyte and the surrounding cumulus cells (CCs). The aim of this study was (i) to investigate maturation markers, such as Cx43 and Cdk4 protein levels, and (ii) to analyze the distribution of these two proteins in CCs cultured for 44, 88, 132, and 164 hours in both separated and cumulus-enclosed oocyte...

article

Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines

Hanna Piotrowska, Malgorzata Kucinska, Marek Murias

Molecular and Cellular Biochemistry > 2013 > 383 > 1-2 > 95-102

The expression of P450 enzymes and antioxidative enzymes in tumour tissue can have a major impact on the responsiveness of tumours to cancer chemotherapeutic drugs, therefore such information may be very precious when experiments are designed. The compressive information, concerning the expression of drug metabolism enzymes or antioxidative enzymes is still lacking, therefore in this study the expression...

article

Resveratrol analogue 3,4,4′,5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV‐3 and A-2780 cancer cells

Hanna Piotrowska, Krzysztof Myszkowski, Alicja Ziółkowska, Katarzyna Kulcenty, more

Toxicology and Applied Pharmacology > 2012 > 263 > 1 > 53-60

In the screening studies, cytotoxicity of 12 methylated resveratrol analogues on 11 human cancer cell lines was examined. The most active compound 3,4,4′5-tetramethoxystilbene (DMU-212) and two ovarian cancer cell lines A-2780 (IC ₅₀ =0.71μM) and SKOV-3 (IC ₅₀ =11.51μM) were selected for further investigation.To determine the mechanism of DMU-212 cytotoxicity, its ability to induce...

article

Biological activity of piceatannol: Leaving the shadow of resveratrol

Hanna Piotrowska, Malgorzata Kucinska, Marek Murias

Mutation Research-Reviews in Mutation Research > 2012 > 750 > 1 > 60-82

Resveratrol (3,4′,5-trans-trihydroxystilbene), a naturally occurring stilbene, is considered to have a number of beneficial effects, including anticancer, anti-aethrogenic, anti-oxidative, anti-inflammatory, anti-microbial and estrogenic activity. Piceatannol (3,3′,4,5′-trans-trihydroxystilbene), a naturally occurring hydroxylated analogue of resveratrol, is less studied than resveratrol but displays...

article

Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats

Jadwiga Jodynis-Liebert, Michal Nowicki, Marek Murias, Teresa Adamska, more

Regulatory Toxicology and Pharmacology > 2010 > 57 > 2-3 > 266-273

The aim of this study was to investigate cytotoxicity, acute and subchronic oral toxicity of an ionic liquid didecyldimethylammonium saccharinate [DDA][Sac] in rat.IC ₅₀ values tested on six human cell lines varied from 1.44μM to 5.47μM. The compound tested was classified to the 4th toxicity class with a fixed LD ₅₀ cut-off value 500mg/kg. Organ pathology induced by [DDA][Sac] in an...

article

Glucocorticoid Receptor α and β Variant Expression Is Associated with ASF/SF2 Splicing Factor Upregulation in HT-29 Colon Cancer and MCF-7 Breast Carcinoma Cells

Hanna Piotrowska, Pawel P. Jagodzinski

Archives of Medical Research > 2009 > 40 > 3 > 156-162

Transcriptional activity of NF-κB is inhibited by the liganded glucocorticoid receptor (GR), which exists mainly in two splice variants as functional GRα and nonfunctional GRβ. We investigated the effect of 5-aza-2′-deoxycytidine (5-dAzaC), trichostatin A (TSA), and sodium butyrate (NaBu) on GRα,GRβ and ASF/SF2 splicing factor expression in HT-29 colon and MCF-7 breast carcinoma cells.HT-29 and MCF-7...

article

Stan ochrony zasobow genowych roślin strefy przybałtyckiej

Wydawnictwo Uniwersytetu Łódzkiego, Hanna Piotrowska, Katedra Ekologii Roślin i Ochrony Przyrody Uniwersytet Gdański

Acta Universitatis Lodziensis. Folia Sozologica > 1986 > 3

The authoress has presented the actual state of reserves, national and nature parks in Pomerania, and discussed the degree of representativeness of these objects for communities and flora of particular geobotanical regions. She considers it the most urgent task to ensure protection for rare species and those being exclusively met in the Baltic zone together with their full taxonomic and phytocenotic...

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