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The molecular basis underlying the rich phase behavior of globular proteins remains poorly understood. We use atomistic multiscale molecular simulations to model the solution‐state conformational dynamics and interprotein interactions of D‐crystallin and its P23T‐R36S mutant, which drastically limits the protein solubility, at both infinite dilution and at a concentration where the mutant fluid phase...
Cancerous tissues undergo extensive changes to their cellular environments that differentiate them from healthy tissues. These changes include changes in extracellular pH and Ca2+ concentrations, and the exposure of phosphatidylserine (PS) to the extracellular environment, which can modulate the interaction of peptides and proteins with the plasma membrane. Deciphering the molecular mechanisms of...