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The X‐linked WTX/AMER1 protein constitutes an important component of the β‐catenin destruction complex that can both enhance and suppress canonical β‐catenin signaling. Somatic mutations in WTX/AMER1 have been found in a proportion of the pediatric kidney cancer Wilms’ tumor. By contrast, germline mutations cause the severe sclerosing bone dysplasia osteopathia striata congenita with cranial sclerosis...
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