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Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca 2+ -binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers. Our NMR structure shows that an S100A4 dimer binds to a single myosin heavy chain in an asymmetrical configuration. NMIIA in the complex forms a continuous helix that stretches across the surface of S100A4...
The interaction between the calcium-binding protein S100A4 and the C-terminal fragments of nonmuscle myosin heavy chain IIA has been studied by equilibrium and kinetic methods. Using site-directed mutants, we conclude that Ca 2+ binds to the EF2 domain of S100A4 with micromolar affinity and that the K d value for Ca 2+ is reduced by several orders of magnitude in the presence...
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