Search results for: David P. Finn

Items from 1 to 20 out of 60 results

article

Why Europe needs a pain research strategy

Gisèle Pickering, Mary O’Keeffe, Kirsty Bannister, Susanne Becker, more

European Journal of Pain > 27 > 10 > 1147 - 1149

article

Major disparities in patient‐reported adherence compared to objective assessment of adherence using mass spectrometry: A prospective study in a tertiary‐referral hypertension clinic

James M. G. Curneen, Louise Rabbitt, Darragh Browne, Darragh F. O'Donoghue, more

British Journal of Clinical Pharmacology > 89 > 7 > 1948 - 1955

Aim Many challenges exist in determining true rates of adherence to antihypertensive medications among individuals in a clinic setting. For the first time, we aimed to compare patient‐reported antihypertensive adherence with objective evidence using mass spectrometry spot urinalysis in a tertiary referral clinic setting. Methods A prospective observational single‐centre cohort study was performed...

article

Is Europe also facing an opioid crisis?—A survey of European Pain Federation chapters

Winfried Häuser, Eric Buchser, David P. Finn, Geerd Dom, more

European Journal of Pain > 25 > 8 > 1760 - 1769

Background There is considerable public interest in whether Europe is facing an opioid crisis comparable to the one in the United States and the contribution of opioid prescriptions for pain to a potential opioid crisis. Methods A task force of the European Pain Federation (EFIC) conducted a survey with its national chapter representatives on trends of opioid prescriptions and of drug‐related emergency...

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Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC)

André Mouraux, Kirsty Bannister, Susanne Becker, David P. Finn, more

European Journal of Pain > 25 > 4 > 731 - 756

For decades, basic research on the underlying mechanisms of nociception has held promise to translate into efficacious treatments for patients with pain. Despite great improvement in the understanding of pain physiology and pathophysiology, translation to novel, effective treatments for acute and chronic pain has however been limited, and they remain an unmet medical need. In this opinion paper bringing...

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Attenuation of fear‐conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB₂ receptors

Louise Corcoran, Darragh Mattimoe, Michelle Roche, David P. Finn

British Journal of Pharmacology > 177 > 10 > 2240 - 2255

Background and Purpose Improved understanding of brain mechanisms regulating endogenous analgesia is important from a fundamental physiological perspective and for identification of novel therapeutic strategies for pain. The endocannabinoid system plays a key role in stress‐induced analgesia, including fear‐conditioned analgesia (FCA), a potent form of endogenous analgesia. Here, we studied the role...

article

PPARs and pain

Bright N Okine, Jessica C Gaspar, David P Finn

British Journal of Pharmacology > 176 > 10 > 1421 - 1442

Chronic pain is a common cause of disability worldwide and remains a global health and socio‐economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or associated with significant adverse side effects. The PPARs, a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and...

article

The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner

Kieran Rea, Fiona McGowan, Louise Corcoran, Michelle Roche, more

British Journal of Pharmacology > 176 > 10 > 1492 - 1505

Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the mPFC [infralimbic (IfL), prelimbic (PrL) and anterior cingulate (ACC) cortices] differentially alter the expression of contextually induced fear and nociceptive behaviour. We investigated...

article

Opposing roles of CB₁ and CB₂ cannabinoid receptors in the stimulant and rewarding effects of cocaine

Pedro H Gobira, Ana C Oliveira, Julia S Gomes, Vivian T Silveira, more

British Journal of Pharmacology > 176 > 10 > 1541 - 1551

Background and Purpose The endocannabinoids anandamide and 2‐arachidonoylglycerol (2‐AG) bind to CB₁ and CB₂ cannabinoid receptors in the brain and modulate the mesolimbic dopaminergic pathway. This neurocircuitry is engaged by psychostimulant drugs, including cocaine. Although CB₁ receptor antagonism and CB₂ receptor activation are known to inhibit certain effects of cocaine, they have been investigated...

article

FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats

Lisa E. Flannery, Daniel M. Kerr, David P. Finn, Michelle Roche

Behavioural Brain Research > 2018 > 353 > C > 11-20

Aberrant activation of toll-like receptor (TLR)s results in persistent and prolonged neuroinflammation and has been implicated in the pathogenesis and exacerbation of psychiatric and neurodegenerative disorders. TLR3 coordinates the innate immune response to viral infection and recent data have demonstrated that inhibiting fatty acid amide hydrolase (FAAH), the enzyme that primarily metabolizes anandamide,...

article

Medication adherence for resistant hypertension: Assessing theoretical predictors of adherence using direct and indirect adherence measures

Hannah Durand, Peter Hayes, Brendan Harhen, Ann Conneely, more

British Journal of Health Psychology > 23 > 4 > 949 - 966

Objectives This study examined theoretical predictors of long‐term medication adherence (i.e., treatment‐related beliefs, coherence of beliefs from experience with medication, habit strength, and pill burden) for patients with apparent treatment‐resistant hypertension in primary care, using a composite adherence score derived from direct and indirect measures (i.e., prescription refill, self‐report,...

article

European Pain Federation (EFIC) position paper on appropriate use of cannabis‐based medicines and medical cannabis for chronic pain management

Winfried Häuser, David P. Finn, Eija Kalso, Nevenka Krcevski‐Skvarc, more

European Journal of Pain > 22 > 9 > 1547 - 1564

Cannabis‐based medicines are being approved for pain management in an increasing number of European countries. There are uncertainties and controversies on the role and appropriate use of cannabis‐based medicines for the management of chronic pain. EFIC convened a European group of experts, drawn from a diverse range of basic science and relevant clinical disciplines, to prepare a position paper...

article

Plasma N‐acylethanolamine and endocannabinoid levels in burning mouth syndrome: Potential role in disease pathogenesis

Alison Barry, Ken D. O'Halloran, Joseph P. McKenna, Christine McCreary, more

Journal of Oral Pathology & Medicine > 47 > 4 > 440 - 442

Objective The objective was to measure endocannabinoid (eCB) ligands and non‐cannabinoid N‐acylethanolamine (NAE) molecules in plasma from individuals with burning mouth syndrome (BMS) and to determine whether plasma eCB/NAE levels correlated with pain, inflammation and depressive symptomatology in this cohort. Study Design Plasma content of the eCBs, anandamide (AEA) and 2‐arachidonoyl‐glycerol...

article

FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex

Lisa E. Flannery, Rebecca J. Henry, Daniel M. Kerr, David P. Finn, more

Journal of Neuroscience Research > 96 > 6 > 989 - 1001

Toll‐like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3‐induced inflammatory, endocrine, and sickness responses. The data revealed that TLR3‐induced expression of interferon‐ or NFkB‐inducible genes (IFN‐α/β, IP‐10, or TNF‐α), either peripherally (spleen) or centrally (hypothalamus), did...

article

The cannabinoid system and pain

Stephen G. Woodhams, Victoria Chapman, David P. Finn, Andrea G. Hohmann, more

Neuropharmacology > 2017 > 124 > C > 105-120

Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects including tolerance, dependence, gastrointestinal dysfunction, cognitive impairment, and a narrow therapeutic window, making the search for novel analgesics...

article

Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

David A. Buckley, Elaine M. Jennings, Nikita N. Burke, Michelle Roche, more

Molecular Neurobiology > 2018 > 55 > 3 > 2431-2431

The online version of the original article can be found at http://dx.doi.org/10.1007/s12035-017-0492-8

article

Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1

Rebecca J. Henry, Daniel M. Kerr, Lisa E. Flannery, Marykate Killilea, more

Brain, Behavior, and Immunity > 2017 > 62 > C > 318-331

Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role for the endocannabinoid system in modulating inflammatory responses including those mediated by TLRs, and thus this system may provide an important treatment target for neuroinflammatory...

article

Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

Nikita N. Burke, David P. Finn, Brian E. McGuire, Michelle Roche

Journal of Neuroscience Research > 95 > 6 > 1257 - 1270

A wealth of research over the past 2 decades has expanded our understanding of the impact of early‐life adversity on physiological function and, consequently, health and wellbeing in later life. Early‐life adversity increases the risk of developing a number of disorders, such as chronic pain, fibromyalgia, and irritable bowel syndrome. Although much of the research has examined the impact of physical...

article

The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

David A. Buckley, Elaine M. Jennings, Nikita N. Burke, Michelle Roche, more

Molecular Neurobiology > 2018 > 55 > 3 > 2420-2430

Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods to reliably facilitate an accurate diagnosis. We therefore aimed to determine the feasibility of a simple diagnostic test by analysing differentially expressed genes in the blood...

article

Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia

Bright N. Okine, Jessica C. Gaspar, Manish K. Madasu, Weredeselam M. Olango, more

Brain Research > 2017 > 1657 > C > 185-192

The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling in the PAG of WKY rats exposed to the formalin test of inflammatory pain, versus...

article

Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat

Nikita N. Burke, Jonathan Coppinger, Daniel R. Deaver, Michelle Roche, more

Physiology & Behavior > 2016 > 167 > C > 28-34

Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress hyperresponsive Wistar-Kyoto (WKY) rat displays hypolocomotion in a novel aversive environment and depressive- and anxiety-like behaviours, which have been mostly characterised in males...

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INFONA - science communication portal

Search results for: David P. Finn

Why Europe needs a pain research strategy

Major disparities in patient‐reported adherence compared to objective assessment of adherence using mass spectrometry: A prospective study in a tertiary‐referral hypertension clinic

Is Europe also facing an opioid crisis?—A survey of European Pain Federation chapters

Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC)

Attenuation of fear‐conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB₂ receptors

PPARs and pain

The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner

Opposing roles of CB₁ and CB₂ cannabinoid receptors in the stimulant and rewarding effects of cocaine

FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats

Medication adherence for resistant hypertension: Assessing theoretical predictors of adherence using direct and indirect adherence measures

European Pain Federation (EFIC) position paper on appropriate use of cannabis‐based medicines and medical cannabis for chronic pain management

Plasma N‐acylethanolamine and endocannabinoid levels in burning mouth syndrome: Potential role in disease pathogenesis

FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex

The cannabinoid system and pain

Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1

Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia

Sex differences and similarities in depressive- and anxiety-like behaviour in the Wistar-Kyoto rat

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