Jan Magdalan

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Cornelian cherry consumption increases the l-arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet

Tomasz Sozański, Alicja Z. Kucharska, Dorota Szumny, Jan Magdalan, more

Journal of Functional Foods > 2017 > 34 > C > 189-196

In our previous publication we showed that the oral administration of cornelian cherry fruits prevented feed-induced atherosclerosis.In this study we have examined the effect of cornelian cherry lyophilisate on proteins responsible for regulation of NO synthesis: asymmetric and symmetric dimethylarginine (ADMA, SDMA) and l-arginine in plasma, and dimethylarginine dimethylaminohydrolase (DDAH) in the...

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Nonfatal and fatal intoxications with pure caffeine – report of three different cases

Jan Magdalan, Marcin Zawadzki, Rafał Skowronek, Magdalena Czuba, more

Forensic Science, Medicine and Pathology > 2017 > 13 > 3 > 355-358

Caffeine is not usually perceived as a drug by most people because it is found in many foods and drinks, including caffeinated energy drinks, as well as in over the counter analgesics and cold preparations. Recently in Poland it has become increasingly common to take pure caffeine, bought through online stores, as a psychoanaleptic. This creates a much higher risk of severe and even fatal poisoning...

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Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation

Tomasz Sozański, Alicja Z. Kucharska, Andrzej Rapak, Dorota Szumny, more

Atherosclerosis > 2016 > 254 > C > 151-160

Cardiovascular benefits of fruits are attributed mainly to their (poly)phenolic constituents, especially anthocyanins. The main aim of our study is to compare effects of iridoids and anthocyanins from one fruit on diet-induced atherosclerosis. The cornelian cherry is a native or cultivated plant that grows in many European countries, used in cuisine and folk medicine. In our previous study, we showed...

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Suicidal overdose with relapsing clomipramine concentrations due to a large gastric pharmacobezoar

Jan Magdalan, Marcin Zawadzki, Tomasz Słoka, Tomasz Sozański

Forensic Science International > 2013 > 229 > 1-3 > e19-e22

The paper presents a case of fatal intoxication after massive sustained-release clomipramine overdosage with prolonged toxicity related to a large gastric pharmacobezoar. 42-year-old female was admitted to the toxicology unit 14h after drugs ingestion. At admission patient was deeply unconscious, required controlled mechanical ventilation. Serum total level of TCAs was 1955ng/mL. Gastric lavage revealed...

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Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures

Jan Magdalan, Aleksandra Piotrowska, Agnieszka GomuŁkiewicz, Tomasz Sozański, more

Experimental and Toxicologic Pathology > 2011 > 63 > 4 > 311-315

High mortality rate in Amanita phalloides (death cap) intoxications is a result of the acute liver failure following hepatocyte damage due to hepatocellular uptake of amatoxins. α-Amanitin (α-AMA), the major amatoxin, blocks a RNA polymerase II, which results in inhibition of transcription of DNA and protein synthesis processes and leads to hepatocyte death. α-AMA is also a strong apoptosis inductor...

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Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene

Eugenia Murawska-CiaŁowicz, Zbigniew Jethon, Jan Magdalan, Lidia Januszewska, more

Experimental and Toxicologic Pathology > 2011 > 63 > 1-2 > 97-103

Benzo(a)pyrene [B(a)P] is a widespread pollutant with a mutagenic, carcinogenic and strong prooxidative properties. The present study evaluated the melatonin effects on lipid peroxidation products levels and on activity of antioxidative enzymes in the course of B(a)P intoxication. Control rats were treated with 0.9% NaCl; another group was given 10mg melatonin/kgbw; a third group was injected twice...

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Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Experimental and Toxicologic Pathology > 2010 > 62 > 4 > 367-373

Fatalities due to mushroom poisonings are increasing worldwide, with high mortality rate resulting from ingestion of amanitin-producing species. Intoxications caused by amanitin-containing mushrooms represent an unresolved problem in clinical toxicology since no specific and fully efficient antidote is available. The objective of this study was a comparative evaluation of benzylpenicillin (BPCN),...

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Vipera berus Bites in the Region of Southwest Poland—A Clinical Analysis of 26 Cases

Jan Magdalan, Małgorzata Trocha, Anna Merwid-Ląd, Tomasz Sozański, more

Wilderness & Environmental Medicine > 2010 > 21 > 2 > 114-119

Vipera berus is the only naturally occurring venomous snake in Poland. Its venom is primarily vasculotoxic and evokes both local and systemic findings. The aim of the study was to review a series of clinical cases of V berus bites occurring in southwest Poland.The charts of 26 patients (age range, 16–66 years; mean, 42 years) hospitalized with V berus bites were retrospectively analyzed using a data...

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Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Ewa Chlebda, Jan Magdalan, Anna Merwid-Ląd, Małgorzata Trocha, more

Experimental and Toxicologic Pathology > 2010 > 62 > 2 > 105-108

Water-soluble quercetin-5′-sulfonic acid sodium salt (NaQSA) and morin-5′-sulfonic acid sodium salt (NaMSA) could exert an antagonistic effect on cadmium intoxication. The aim of the study was to examine the influence of these substances on superoxide dismutase (SOD) and glutathione (GSH) levels in the mouse liver in the subacute cadmium intoxication model. NaQSA and NaMSA significantly counteracted...

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Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Archives of Toxicology > 2009 > 83 > 12 > 1091-1096

The most often used antidote to treat poisoning caused by amanitin-containing mushrooms is benzylpenicillin (BPCN). However, a very few reports suggest that other antibiotics such as ceftazidime (CEFT) and rifamycin SV (RIFSV) show better antidote activity against amanitins than BPCN. Given this, there is an ongoing debate as which of three antidotes is optimal for treatment of such poisonings. In...

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Early morphological and functional alterations in canine hepatocytes due to α-amanitin, a major toxin of Amanita phalloides

Jan Magdalan, Alina Ostrowska, Marzena Podhorska-Okołów, Aleksandra Piotrowska, more

Archives of Toxicology > 2009 > 83 > 1 > 55-60

The toadstool death cap (Amanita phalloides) and its subspecies, destroying angel (A. virosa) and death angel (A. verna) are responsible for nearly 95% of all fatal mushroom poisonings. High mortality rate in A. phalloides intoxications is principally a result of the acute liver failure following significant hepatocyte damage due to hepatocellular uptake of amanitins, the major toxins of this mushroom...

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Search results for: Jan Magdalan

Cornelian cherry consumption increases the l-arginine/ADMA ratio, lowers ADMA and SDMA levels in the plasma, and enhances the aorta glutathione level in rabbits fed a high-cholesterol diet

Nonfatal and fatal intoxications with pure caffeine – report of three different cases

Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation

Suicidal overdose with relapsing clomipramine concentrations due to a large gastric pharmacobezoar

Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures

Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene

Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Vipera berus Bites in the Region of Southwest Poland—A Clinical Analysis of 26 Cases

Influence of water-soluble flavonoids, quercetin-5′-sulfonic acid sodium salt and morin-5′-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model

Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin

Early morphological and functional alterations in canine hepatocytes due to α-amanitin, a major toxin of Amanita phalloides

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