The main function of cells in the skin called sebocytes is considered to be the production of lipids (oils) to moisturize the skin. It used to be thought that they were bystander cells during skin inflammation with no impact on the body's immune response, meaning they did not help the body to fight off signs of infection on inflammation. However, it recently became apparent that sebocytes do in fact...
The main function of sebocytes is considered to be the production of lipids to moisturize the skin. However, it recently became apparent that sebocytes release chemokines and cytokines and respond to proinflammatory stimuli as well as the presence of bacteria.
To analyse the functional communication between human sebocytes and T cells.
Signals generated by both antigen and cytokines binding to CD4 + T cells synergize to promote helper T cell subset differentiation. For Th2 cell commitment neither IL-4 nor T cell receptor (TCR) stimulation are sufficient to drive differentiation. Th2 differentiation requires IL-4-receptor mediated signal transducers and activators of transcription 6 (STAT6) activation, but the possibility...
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.