Hira Lal Goel

chapter

Integrin Signaling in Cancer

Hira Lal Goel, Lucia R. Languino

Cancer Treatment and Research > Molecular Targeting and Signal Transduction > 15-31

Conclusions This review highlights the current knowledge of the alterations that occur in cancer and that involve integrins and integrin-activated pathways. Integrins are cell surface receptors for ECM proteins that mediate a variety of functions related to cell proliferation, differentiation, and survival. Although the specific functions of integrins and their ligands in cancer need to be further...

article

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer

Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, more

Cell Reports > 2016 > 14 > 9 > 2193-2208

Autocrine VEGF signaling is critical for sustaining prostate and other cancer stem cells (CSCs), and it is a potential therapeutic target, but we observed that CSCs isolated from prostate tumors are resistant to anti-VEGF (bevacizumab) and anti-VEGFR (sunitinib) therapy. Intriguingly, resistance is mediated by VEGF/neuropilin signaling, which is not inhibited by bevacizumab and sunitinib, and it involves...

chapter

Integrin Signaling in Cancer

Hira Lal Goel, Lucia R. Languino

Cancer Treatment and Research > Molecular Targeting and Signal Transduction > 15-31

Conclusions This review highlights the current knowledge of the alterations that occur in cancer and that involve integrins and integrin-activated pathways. Integrins are cell surface receptors for ECM proteins that mediate a variety of functions related to cell proliferation, differentiation, and survival. Although the specific functions of integrins and their ligands in cancer need to be further...

article

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

Matthew W. Parker, Andrew D. Linkugel, Hira Lal Goel, Tingting Wu, more

Structure > 2015 > 23 > 4 > 677-687

Vascular endothelial growth factor C (VEGF-C) is a potent lymphangiogenic cytokine that signals via the coordinated action of two cell surface receptors, Neuropilin-2 (Nrp2) and VEGFR-3. Diseases associated with both loss and gain of VEGF-C function, lymphedema and cancer, respectively, motivate studies of VEGF-C/Nrp2 binding and inhibition. Here, we demonstrate that VEGF-C binding to Nrp2 is regulated...

article

Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells

Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, more

Cell Reports > 2014 > 7 > 3 > 747-761

Although the α6β1 integrin has been implicated in the function of breast and other cancer stem cells (CSCs), little is known about its regulation and relationship to mechanisms involved in the genesis of CSCs. We report that a CD44^high/CD24^low population, enriched for CSCs, is comprised of distinct epithelial and mesenchymal populations that differ in expression of the two α6 cytoplasmic domain splice...

article

β₁ integrins mediate resistance to ionizing radiation in vivo by inhibiting c‐Jun amino terminal kinase 1

Hira Lal Goel, Aejaz Sayeed, Michael Breen, Matthew J. Zarif, more

Journal of Cellular Physiology > 228 > 7 > 1601 - 1609

This study was carried out to dissect the mechanism by which β₁ integrins promote resistance to radiation. For this purpose, we conditionally ablated β₁ integrins in the prostatic epithelium of transgenic adenocarcinoma of mouse prostate (TRAMP) mice. The ability of β₁ to promote resistance to radiation was also analyzed by using an inhibitory antibody to β₁, AIIB2, in a xenograft model. The role...

article

β1 integrins mediate cell proliferation in three‐dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1

Hira Lal Goel, Jean M. Underwood, Jeffrey A. Nickerson, Chung‐Cheng Hsieh, more

Journal of Cellular Physiology > 224 > 1 > 210 - 217

The β1 integrins play an important role in the modulation of cancer cell proliferation and tumor growth. We have previously shown that β1 integrins associate with insulin‐like growth factor type 1 receptor (IGF‐IR) and regulate IGF‐stimulated prostate cancer cell proliferation. In the present study, we find that downregulation of β1 in prostate cancer cells inhibits IGF‐IR and AKT activation. We also...

article

Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer

Irwin Leav, Janet Plescia, Hira Lal Goel, Jing Li, more

The American Journal of Pathology > 2010 > 176 > 1 > 393-401

Molecular chaperones of the heat shock protein-90 (Hsp90) family promote cell survival, but the molecular requirements of this pathway in tumor progression are not understood. Here, we show that a mitochondria-localized Hsp90 chaperone, tumor necrosis factor receptor-associated protein-1 (TRAP-1), is abundantly and ubiquitously expressed in human high-grade prostatic intraepithelial neoplasia, Gleason...

article

PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK, Cas, and paxillin, formation of Cas-CRK complex, and JNK activation

Hira Lal Goel, Chinmoy Sankar Dey

Differentiation > 2002 > 70 > 6 > 257-271

Previous reports suggest that PKC plays an important role in regulating myogenesis. However, the regulatory signaling pathways are not fully understood. We examined the effects of PKC downregulation on signaling events during skeletal muscle differentiation. We found that downregulation of PKC results in increased myogenesis in C2C12 cells as measured by creatine kinase activity and myogenin expression...

article

INSULIN-MEDIATED TYROSINE PHOSPHORYLATION OF MYOSIN HEAVY CHAIN AND CONCOMITANT ENHANCED ASSOCIATION OF C-TERMINAL SRC KINASE DURING SKELETAL MUSCLE DIFFERENTIATION

Hira Lal Goel, Chinmoy Sankar Dey

Cell Biology International > 2002 > 26 > 6 > 557-561

In this study, we present for the first time: (1) evidence regarding tyrosine phosphorylation of myosin heavy chain, (2) evidence that insulin can phosphorylate myosin, (3) association of myosin with Csk, a signalling molecule, (4) modulation of this association by insulin, and (5) evidence that these interactions are associated with skeletal muscle differentiation.

article

Role of protein kinase C during insulin mediated skeletal muscle cell spreading

Hira Lal Goel, Chinmoy Sankar Dey

Journal of Muscle Research and Cell Motility > 2002 > 23 > 4 > 269-277

Protein kinase C (PKC) is known to play important roles in integrin mediated cell spreading. This study investigated the role of PKC during insulin mediated muscle cell spreading, which was independent of integrin α5. We found that PKC-α becomes active and localise to membrane during insulin mediated cell spreading. We also found that PKC activation is essential for cell spreading stimulated by insulin...

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Search results for: Hira Lal Goel

Integrin Signaling in Cancer

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer

Integrin Signaling in Cancer

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells

β₁ integrins mediate resistance to ionizing radiation in vivo by inhibiting c‐Jun amino terminal kinase 1

β1 integrins mediate cell proliferation in three‐dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1

Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer

PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK, Cas, and paxillin, formation of Cas-CRK complex, and JNK activation

INSULIN-MEDIATED TYROSINE PHOSPHORYLATION OF MYOSIN HEAVY CHAIN AND CONCOMITANT ENHANCED ASSOCIATION OF C-TERMINAL SRC KINASE DURING SKELETAL MUSCLE DIFFERENTIATION

Role of protein kinase C during insulin mediated skeletal muscle cell spreading

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