We have produced soluble T cell receptor (TCR) derived from a human CD8 + cytotoxic T lymphocyte (CTL) clone D3 that recognizes the immunodominant HIV Gag peptide SLYNTVATL (SL9) in association with major histocompatibility complex (MHC) class I protein HLA-A2. Drosophila Schneider cells (S2) were used to express genes coding the TCR α and β chains under an inducible promoter. Both chains...
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