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Recent studies suggest that soluble intermediates formed during amyloid β-protein (Aβ) fibrillogenesis are neurotoxic. We studied early aggregation assemblies of wild-type and mutant Aβ bearing the E22G (“Arctic”) familial Alzheimer's disease mutation. Using a novel method to present purified, disaggregated Aβ peptides to primary cortical neurons, the detailed temporal pattern of neurotoxicity was...