Search results for: Fumio Kanda

Items from 1 to 20 out of 36 results

article

Progressive length‐dependent polyneuropathy in xeroderma pigmentosum group A

Yukio Tsuji, Takehiro Ueda, Kenji Sekiguchi, Masahiro Nishiyama, more

Background In this study, we aimed to investigate the progression of peripheral nervous system involvement in xeroderma pigmentosum group A (XP‐A). Methods We performed nerve conduction studies in 17 genetically confirmed XP‐A patients and conducted follow‐ups. Of these patients we also analyzed gray matter volume (GMV) using brain MRI and assessed the severity score of clinical and skin manifestation...

article

Therapeutic regimen of l-arginine for MELAS: 9-year, prospective, multicenter, clinical research

Yasutoshi Koga, Nataliya Povalko, Eisuke Inoue, Hidefumi Nakamura, more

Journal of Neurology > 2018 > 265 > 12 > 2861-2874

Objective To examine the efficacy and safety of the therapeutic regimen using oral and intravenous l-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Methods In the presence and absence of an ictus of stroke-like episodes within 6 h prior to efficacy assessment, we correspondingly conducted the systematic administration...

article

Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study

Hironobu Endo, Kenji Sekiguchi, Hitoshi Shimada, Takehiro Ueda, more

Journal of Neurology > 2018 > 265 > 3 > 552-561

There is no reliable objective indicator for upper motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). To determine the clinical significance and potential utility of magnetic resonance (MR) signals, we investigated the relationship between clinical symptoms and susceptibility changes in the motor cortex measured using susceptibility-weighted MR imaging taken by readily available 3-T...

article

Quantitative analysis of brain atrophy in patients with xeroderma pigmentosum group A carrying the founder mutation in Japan

Takehiro Ueda, Fumio Kanda, Masahiro Nishiyama, Chikako Nishigori, more

Journal of the Neurological Sciences > 2017 > 381 > C > 103-106

Xeroderma pigmentosum (XP) is an inherited congenital disease presenting with dermatological and neurological manifestations. In Japan, XP complementation group A (XP-A) is most frequently observed in eight clinical subtypes, and the homozygous founder mutation, IVS3-1G>C in XPA, suffer from severe manifestations including progressive brain atrophy since childhood. In this study, we used magnetic...

article

Xeroderma pigmentosum clinical practice guidelines

Shinichi Moriwaki, Fumio Kanda, Masaharu Hayashi, Daisuke Yamashita, more

The Journal of Dermatology > 44 > 10 > 1087 - 1096

Xeroderma pigmentosum (XP) is a genetic photosensitive disorder in which patients are highly susceptibe to skin cancers on the sun‐exposed body sites. In Japan, more than half of patients (30% worldwide) with XP show complications of idiopathic progressive, intractable neurological symptoms with poor prognoses. Therefore, this disease does not merely present with dermatological symptoms, such as photosensitivity,...

article

Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy

Yoshikatsu Noda, Kenji Sekiguchi, Hideki Tokuoka, Tetsuya Oda, more

Journal of the Neurological Sciences > 2017 > 377 > C > 1-5

Spontaneous anterior interosseous nerve (AIN) palsy develops following the resolution of nerve pain, which may be considered as distal neuralgic amyotrophy. NA is assumed to have a complex etiology, but an autoimmune mechanism is likely involved. However, precise assessment of the lesion is challenging. We examined five consecutive patients with suspected spontaneous AIN palsy using ultrasonography...

article

A mild case of Cockayne syndrome

Mariko Tsujimoto, Eiji Nakano, Taro Masaki, Fumio Kanda, more

Journal of Dermatological Science > 2017 > 86 > 2 > e52-e53

article

Dopamine transporter imaging as a diagnostic modality for atypical Alzheimer's disease mimicking corticobasal degeneration

Kazuo Washida, Hisatomo Kowa, Yasuji Yamamoto, Fumio Kanda, more

Psychogeriatrics > 17 > 1 > 73 - 75

article

Multiple Deep White Matter Hyperintense Lesions on Diffusion-Weighted Imaging: Early Sign of Straight Sinus Thrombosis

Kazuo Washida, Hisatomo Kowa, Yukio Tsuji, Kenji Sekiguchi, more

Journal of Stroke and Cerebrovascular Diseases > 2016 > 25 > 9 > e131-e133

Straight sinus thrombosis (SST) is a rare type of cerebral venous sinus thromboses and is extremely difficult to diagnose, especially at its acute stage. The diagnosis is often delayed in many cases of SST that leads to treatment delay and a poor prognosis. We report the case of a 67-year-old patient who had multiple deep white matter (DWM) hyperintense signals on diffusion-weighted imaging (DWI)...

article

Ultrasonographic diaphragm thickness correlates with compound muscle action potential amplitude and forced vital capacity

Yoshikatsu Noda, Kenji Sekiguchi, Nobuo Kohara, Fumio Kanda, more

Muscle & Nerve > 53 > 4 > 522 - 527

Introduction: Noninvasive evaluation of respiratory function in patients with various neuromuscular disorders is important for predicting life expectancy. Methods: We performed B‐mode ultrasonography (USG) and nerve conduction studies in 37 patients (16 had amyotrophic lateral sclerosis; 11, myopathy; and 10, neuropathy) and 10 controls. USG of the diaphragm was performed in the supine position using...

article

1-A-D-3. An ultrasonography with nerve conduction study on the diaphragm in neuromuscular disorders

Yoshikatsu Noda, Kenji Sekiguchi, Nobuo Kohara, Hisatomo Kowa, more

Clinical Neurophysiology > 2015 > 126 > 6 > e57

An ultrasonography (USG) with nerve conduction study, in addition to a standard pulmonary function test, was performed to evaluate diaphragm function in various neuromuscular disorders.We evaluated 25 neuromuscular patients: 12 amyotrophic lateral sclerosis, 3 myasthenia gravis, 3 myopathy, 3 neuropathy, and 3 central nervous system disorders. USG of the diaphragm was performed in a supine position...

article

Association of the ASCO Classification with the Executive Function Subscores of the Montreal Cognitive Assessment in Patients with Postischemic Stroke

Kazuo Washida, Masafumi Ihara, Hisatsugu Tachibana, Kenji Sekiguchi, more

Journal of Stroke and Cerebrovascular Diseases > 2014 > 23 > 9 > 2250-2255

The ASCO classification can evaluate the etiology and mechanisms of ischemic stroke more comprehensively and systematically than conventional stroke classification systems such as Trial of Org 10172 in Acute Stroke Treatment (TOAST). Simultaneously, risk factors for cognitive impairment such as arterial sclerosis, leukoaraiosis, and atrial fibrillation can also be gathered and graded using the ASCO...

article

Lower motor neuron syndrome associated with IgG anti-GM1 antibodies revisited

Nobuhiro Yuki, Chiaki Yanaka, Makoto Sudo, Miyuki Funakoshi, more

Journal of Neuroimmunology > 2014 > 272 > 1-2 > 62-66

A patient, who developed an amyotrophic lateral sclerosis-like disorder subsequent to ganglioside treatment, had IgM antibodies to GM2 as well as to minor gangliosides X1 and X2 containing GM2 epitope. These gangliosides as well as GM1 were tested in 655 sera obtained from patients who were suspected of having amyotrophic lateral sclerosis or motor neuron disease to find a treatable condition. Three...

article

WS2-1. A case of slowly progressive muscular atrophy in post hematopoietic stem cell transplantation: Electrophysiological and pathological findings in musculoskeletal chronic graft-versus-host disease (cGVHD)

Kenji Sekiguchi, Maki Kanzawa, Ichizo Nishino, Fumio Kanda, more

Clinical Neurophysiology > 2013 > 124 > 8 > e29

A 38-year-old man who received bone marrow transplantation four years ago for acute lymphocytic leukemia. He felt muscle cramps and became a bed-bound state because of progressing polyarthralgia in the following year. Marked muscle atrophies, mild weakness, joint contractures, and sclerotic skin changes were noted. Motor conduction studies revealed reduction in the amplitude (2.4mV), in the conduction...

article

Zonisamide improves parkinsonism of DLB/PDD without worsening psychiatric symptoms

Hisatomo Kowa, Fumio Kanda, Tatsushi Toda

Alzheimer's & Dementia > 2013 > 9 > 4(S) > P804

article

Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy

Takeshi Uenaka, Hisatomo Kowa, Kenji Sekiguchi, Kakuya Nagata, more

Muscle & Nerve > 47 > 5 > 766 - 768

IntroductionAntimitochondrial antibodies are autoantibodies detected in 90% of primary biliary cirrhosis (PBC) patients. Some PBC cases are complicated by myositis, which is difficult to confirm due to minimal histological evidence of inflammation in limb muscles. MethodsOur aim was to determine the extent of inflammatory changes in a truncal muscle biopsy specimen from a PBC patient. ResultsA 48‐year‐old...

article

A novel mutation in the C2 domain of protein kinase C gamma associated with spinocerebellar ataxia type 14

Takehiro Ueda, Tsuneyoshi Seki, Kimitaka Katanazaka, Kenji Sekiguchi, more

Journal of Neurology > 2013 > 260 > 6 > 1664-1666

article

Clinical Features of Late-onset Poststroke Seizures

Shiho Okuda, Shin Takano, Masao Ueno, Hirotoshi Hamaguchi, more

Journal of Stroke and Cerebrovascular Diseases > 2012 > 21 > 7 > 583-586

Compared to the patients with early-onset seizures (ES), those with late-onset seizures (LS) have a high risk of epilepsy that is a feared complication after stroke. However, few studies have described detailed clinical features of LS in Japanese patients.To elucidate the clinical features of LS, a series of 448 stroke patients (cerebral infarction n = 286; cerebral hemorrhage n = 162) in our hospital...

article

Fibrillation potentials of denervated rat skeletal muscle are associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5

Kenji Sekiguchi, Fumio Kanda, Shigeru Mitsui, Nobuo Kohara, more

Clinical Neurophysiology > 2012 > 123 > 8 > 1650-1655

The molecular mechanisms underlying fibrillation potentials are still unclear. We hypothesised that expression of the cardiac-type voltage-gated sodium channel isoform Nav1.5 in denervated rat skeletal muscle is associated with the generation of such potentials.Muscle samples were extracted and analysed biologically from surgically denervated rat extensor digitorum longus muscle after concentric needle...

article

3. Comparison in placement location of disposable surface electrode in antidromic sensory nerve conduction study

Kenji Sekiguchi, Toko Miyawaki, Mariko Takata, Akihiro Nomura, more

Clinical Neurophysiology > 2011 > 122 > 8 > e9-e10

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INFONA - science communication portal

Search results for: Fumio Kanda

Progressive length‐dependent polyneuropathy in xeroderma pigmentosum group A

Therapeutic regimen of l-arginine for MELAS: 9-year, prospective, multicenter, clinical research

Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study

Quantitative analysis of brain atrophy in patients with xeroderma pigmentosum group A carrying the founder mutation in Japan

Xeroderma pigmentosum clinical practice guidelines

Ultrasonographic findings of proximal median neuropathy: A case series of suspected distal neuralgic amyotrophy

A mild case of Cockayne syndrome

Dopamine transporter imaging as a diagnostic modality for atypical Alzheimer's disease mimicking corticobasal degeneration

Multiple Deep White Matter Hyperintense Lesions on Diffusion-Weighted Imaging: Early Sign of Straight Sinus Thrombosis

Ultrasonographic diaphragm thickness correlates with compound muscle action potential amplitude and forced vital capacity

1-A-D-3. An ultrasonography with nerve conduction study on the diaphragm in neuromuscular disorders

Association of the ASCO Classification with the Executive Function Subscores of the Montreal Cognitive Assessment in Patients with Postischemic Stroke

Lower motor neuron syndrome associated with IgG anti-GM1 antibodies revisited

WS2-1. A case of slowly progressive muscular atrophy in post hematopoietic stem cell transplantation: Electrophysiological and pathological findings in musculoskeletal chronic graft-versus-host disease (cGVHD)

Zonisamide improves parkinsonism of DLB/PDD without worsening psychiatric symptoms

Myositis with antimitochondrial antibodies diagnosed by rectus abdominis muscle biopsy

A novel mutation in the C2 domain of protein kinase C gamma associated with spinocerebellar ataxia type 14

Clinical Features of Late-onset Poststroke Seizures

Fibrillation potentials of denervated rat skeletal muscle are associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5

3. Comparison in placement location of disposable surface electrode in antidromic sensory nerve conduction study

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