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An electrophilic fragment library of small heterocycles was developed and characterized in the surrogate GSH‐reactivity assay and aqueous stability test that revealed their potential as covalent warheads. Screening the library against MurA from Staphylococcus aureus (MurASA) and Escherichia coli (MurAEC) identified heterocyclic fragments with significant inhibitory potency. The validated heterocyclic...
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