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OBJECTIVE To study the efficiency of silencing survivin gene expression by an anti-survivin small RNA expression plasmid and to examine its impact on apoptosis, proliferation and invasive ability of the SW480 colorectal cancer cell line. METHODS An expression plasmid of survivin siRNA (pRNAT/sur-siRNA) was constructed and transduced into SW480 cells. Western blot analysis and a semi-quantitative...
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