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The discovery of neocentromere activity by maize knobs heralded the field of meiotic drive, in which selfish genetic elements exploit meiotic asymmetry to enhance their propagation. A new study reveals the long-awaited basis of this meiotic drive: cytoskeletal motors enable neocentromeric knobs to achieve favorable meiotic positioning and preferential inheritance.
The architecture and nucleotide-dependent conformational changes of the dynein motor domain were recently resolved in several recent structural studies.Dynein displays conspicuous differences from kinesin and myosin, including the independent stepping behavior of the two motor domains in the homodimer, its much weaker directional bias, and the long separation between the polymer-binding domain and...
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