Search results for: Helmut L. Laurer

Items from 1 to 11 out of 11 results

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Outcome after operative treatment of Vancouver type B1 and C periprosthetic femoral fractures: open reduction and internal fixation versus revision arthroplasty

Helmut L. Laurer, Sebastian Wutzler, Susann Possner, Emanuel V. Geiger, more

Archives of Orthopaedic and Trauma Surgery > 2011 > 131 > 7 > 983-989

Introduction The rate of periprosthetic femoral fractures after hip arthroplasty is rising and the estimated current lifetime incidence is 0.4–2.1%. While most authors recommend revision arthroplasty in patients with loose femoral shaft components, treatment options for patients with stable stem are not fully elucidated. Method Against this background we performed a retrospective chart analysis...

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Prehospital and Early Clinical Care of Infants, Children, and Teenagers Compared to an Adult Cohort

Hendrik Wyen, Heike Jakob, Sebastian Wutzler, Rolf Lefering, more

European Journal of Trauma and Emergency Surgery > 2010 > 36 > 4 > 300-307

Background: Although the incidence of pediatric patients in emergency services is as low as 5–10%, trauma remains one of the leading causes of death during childhood. Only a few reports exist about the quality of the initial treatment of pediatric trauma patients. Therefore, we tested the hypothesis of whether prehospital treatment and emergency management in pediatric trauma patients is similar...

article

Periprosthetic humeral fractures after shoulder arthroplasty: operative management and functional outcome

Sebastian Wutzler, Helmut L. Laurer, Stefan Huhnstock, Emanuel V. Geiger, more

Archives of Orthopaedic and Trauma Surgery > 2009 > 129 > 2 > 237-243

Background Currently, little information is available on functional outcome of periprosthetic humeral fractures after shoulder arthroplasty. This investigation aimed to evaluate functional and radiological outcome and patients’ satisfaction following this type of injury treated by open reduction and internal fixation. Methods Retrospective chart analysis of patients treated at two level-I trauma...

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Changes in cortical and subcortical energy metabolism after repetitive and single controlled cortical impact injury in the mouse

Jérôme Manville, Helmut L. Laurer, Wolf-Ingo Steudel, Angelika E. M. Mautes

Journal of Molecular Neuroscience > 2007 > 31 > 2 > 95-100

In the present investigation we examined regional ATP, glucose, and lactate content in the cortical and subcortical region, in a mouse model of controlled cortcal impact (CCI) injury. In serial tissue sections, bioluminescence imaging of ATP, glucose, and lactate was performed 1 h after a single CCI injury or sham surgery and 15 min, 1, 24, and 48 h after the induction of a second CCI injury 24 h...

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Fracture and retrosternal dislocation of the medial clavicle in a 12-year-old child—case report, options for diagnosis, and treatment in children

Mark Lehnert, Bernd Maier, Heike Jakob, Marcus Maier, more

Journal of Pediatric Surgery > 2005 > 40 > 11 > e1-e3

We report a retrosternally displaced epiphysiolysis in a 12-year-old child and discuss options for the most appropriate diagnostic and therapeutic approach. If a standard anteroposterior view of the shoulder girdle shows abnormalities or if appropriate clinical suspicion is present, we strongly favor an magnetic resonance imaging study for further workup instead of a computed tomographic scan, which...

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Effects of underwater sound exposure on neurological function and brain histology

Helmut L. Laurer, Andrew N. Ritting, Andrew B. Russ, Florence M. Bareyre, more

Ultrasound in Medicine & Biology > 2002 > 28 > 7 > 965-973

To evaluate the safety of sonar exposure from a neurological perspective, the vulnerability of the central nervous system to underwater exposure with high-intensity, low-frequency sound (HI-LFS) was experimentally examined. Physiological, behavioral and histological parameters were measured in anesthetized, ventilated rats exposed to brief (5 min), underwater HI-LFS. Exposure to 180 dB sound pressure...

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Rapid Loss and Partial Recovery of Neurofilament Immunostaining Following Focal Brain Injury in Mice

Jimmy W. Huh, Helmut L. Laurer, Ramesh Raghupathi, Mark A. Helfaer, more

Experimental Neurology > 2002 > 175 > 1 > 198-208

Neurofilaments (NF), the intermediate filaments of the neuronal cytoskeleton, provide mechanical stability to the cell. High-molecular-weight NF (NFH) comprises a heavily phosphorylated carboxyl terminal (“sidearm”) domain which helps determine interfilament spacing distances. Experimental evidence suggests that dephosphorylation greatly increases the rate and extent of proteolysis of NFH. Because...

article

Changes in regional energy metabolism after cortical cold lesion in the rat brain

Martin R. Weinzierl, Helmut L. Laurer, Michael Fuchs, Wolf-Ingo Steudel, more

Journal of Molecular Neuroscience > 2002 > 18 > 3 > 247-250

In the present investigation, regional ATP, glucose, and lactate contents were examined in the cortical and subcortical structures after cold lesion in rats. Bioluminescence imaging of ATP, glucose, and lactate was performed in serial tissue sections at 4 h (n=4), 12 h (n=4) and 24 h (n=4) after cold injury or sham surgery. Bioluminescence images were analyzed by computer-assisted densitometry, at...

article

The duality of the inflammatory response to traumatic brain injury

Philipp M. Lenzlinger, Maria-Cristina Morganti-Kossmann, Helmut L. Laurer, Tracy K. McIntosh

Molecular Neurobiology > 2001 > 24 > 1-3 > 169-181

One and a half to two million people sustain a traumatic brain injury (TBI) in the US each year, of which approx 70,000–90,000 will suffer from long-term disability with dramatic impacts on their own and their families’ lives and enormous socio-economic costs. Brain damage following traumatic injury is a result of direct (immediate mechanical disruption of brain tissue, or primary injury) and indirect...

article

Models of Traumatic Brain Injury

Helmut L. Laurer, Philipp M. Lenzlinger, Tracy K. McIntosh

European Journal of Trauma and Emergency Surgery > 2000 > 26 > 3 > 95-110

We present a review of the currently popular preclinical models of non-penetrating traumatic brain injury (TBI). This article focuses on animal models that cause TBI by applying mechanical energy to the head, skull or dura. It attempts to provide a compendium of the main characteristics of each of these experimental models of TBI in respect to acute and chronic histological findings and behavioral...

article

Sequential Changes and Pattern of Bone-Specific Alkaline Phosphatase after Trauma

Helmut L. Laurer, Olivier Hagenbourger, Sabine Quast, Wolfgang Herrmann, more

European Journal of Trauma and Emergency Surgery > 2000 > 26 > 1 > 33-38

Serum activity of bone specific alkaline phosphatase, a product of differentiated osteoblasts, is thought to mirror fracture healing. The precise time course after various conditions involving bone healing is, however, poorly described. The aim of our study was to evaluate sequential changes of bone alkaline phosphatase over a period of 20 weeks in traumatized patients with and without bone injuries...

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Keywords

ATP (2)
COMPLICATIONS (2)
GLUCOSE (2)
LACTATE (2)
RAT (2)
TRAUMATIC BRAIN INJURY (2)
ALKALINE PHOSPHATASE BONE LECTIN PRECIPITATION FRACTURE OSTEOBLAST ACTIVITY (1)
ASTROCYTES (1)
BLOOD BRAIN BARRIER (1)
BRAIN (1)
CENTRAL NERVOUS SYSTEM (1)
CLASSIFICATION (1)
COGNITION (1)
COLD LESION (1)
CONTROLLED CORTICAL IMPACT (1)
CONTROLLED CORTICAL IMPACT INJURY (1)
CYTOKINES (1)
CYTOSKELETON (1)
HIP REPLACEMENT (1)
HISTOLOGY (1)
HUMERAL FRACTURE (1)
IMMUNOHISTOCHEMISTRY (1)
INFLAMMATION (1)
INTERLEUKIN-6 (1)
KEY WORDS EXPERIMENTAL MODELS RODENT TRAUMATIC BRAIN INJURY (1)
MICROGLIA (1)
MOUSE (1)
MULTIPLE TRAUMA (1)
NEUROFILAMENT (1)
NEUROLOGICAL MOTOR FUNCTION (1)
NEURONS (1)
PEDIATRIC (1)
PEDIATRIC TRAUMA (1)
PERIPROSTHETIC (1)
PERIPROSTHETIC FEMORAL FRACTURE (1)
PHOSPHORYLATION (1)
PHYSIOLOGY (1)
POLYTRAUMA MANAGEMENT INCLUDING PREHOSPITAL AND SHOCKROOM (1)
PREHOSPITAL CARE (1)
REPETITIVE (1)
REVISION ARTHROPLASTY (1)
SHOULDER ARTHROPLASTY (1)
TRANSFORMING GROWTH FACTOR-Β (1)
TRAUMA (1)
TUMOR NECROSIS FACTOR-Α (1)
VANCOUVER CLASSIFICATION (1)
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Data set

Springer (8)
Elsevier (3)

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Search results for: Helmut L. Laurer

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