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Mutations in RYR1 are the most common overall cause of congenital myopathy. Dominant mutations are most often associated with central core disease and malignant hyperthermia. Several genotype–phenotype correlations have been identified for these mutations, while less is known about recessive mutations. Thus far, no systematic examinations on recessive mutations have been performed.A large cohort of...
Twenty consecutive patients with impairment of median motor function by clinical or electrophysiologic examination underwent two methods of Motor Unit Number Estimate (MUNE) determination, and were compared with age matched normal subjects after a brief clinical history, neurologic examination and standard nerve conduction studies. Both methods compared the area of average Single Motor Unit Potentials...
Twenty consecutive patients with impairment of median motor function by clinical or electrophysiologic examination underwent two methods of Motor Unit Number Estimate (MUNE) determination, and were compared with age matched normal subjects after a brief clinical history, neurologic examination and standard nerve conduction studies. Both methods compared the area of average Single Motor Unit Potentials...
A loss of motor units is an essential part of most neurogenic disorders of the anterior horn cell, plexus, and peripheral nerve. Standard nerve conduction study amplitudes provide a coarse, but quantitative estimate of the loss of motor units in neurogenic disease. Needle electromyography (EMG) provides a more reliable, but entirely subjective measure of the loss of motor units. In recent years a...
Objective: Define the best electrode montage for monitoring scalp somatosensory evoked potentials (SEP) during spine surgery. Methods: Tibial and ulnar (SEP) were recorded from neck and scalp on 100 consecutive patients undergoing cervical, thoracic or lumbar spine surgery. Continuous recordings were made from standard electrode locations at CZ-FZ, C3-FZ, and C4-FZ simultaneous with recordings from...
During the course of spine surgery, damage to the cord or roots may occur rapidly and irreversibly. The ideal cord monitoring system should allow rapid detection of a signal in the electrically hostile environment of the operating. Monitoring methods need to minimize interference with the surgical procedure. Monitoring techniques entirely outside the surgical field are preferred.The reproducibility...
The number of motor units in a muscle can be estimated by a number of simple, straight forward methods during standard nerve conduction studies. The simplest of these require almost no additional time or effort, but give only gross estimates that cannot be considered quantitative. Each of the methods providing quantitative motor unit number estimates (MUNE), require more time and effort.This workshop...
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